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BCX1777
Known as:
BCX-1777
National Institutes of Health
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Related topics
Related topics
2 relations
forodesine hydrochloride
Broader (1)
immucillin H
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiols.
Z. Gregus
,
Goedele Roos
,
P. Geerlings
,
B. Németi
Toxicological sciences : an official journal of…
2009
Corpus ID: 25488144
Enzymes catalyzing the phosphorolytic cleavage of their substrates can reduce arsenate (AsV) to the more toxic arsenite (AsIII…
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Review
2008
Review
2008
Novel purine nucleoside analogues for hematological malignancies.
A. Korycka
,
E. Lech-Marańda
,
T. Robak
Recent patents on anti-cancer drug discovery
2008
Corpus ID: 25281422
Recently, the search for more effective and safer antineoplastic agents has led to synthesis and introduction into preclinical…
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Review
2007
Review
2007
Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application.
A. Korycka
,
J. Błoński
,
T. Robak
Mini reviews in medicinal chemistry
2007
Corpus ID: 12997426
Recently a few new purine nucleoside analogues (PNA) have been synthesized and introduced into preclinical and clinical trials…
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2006
2006
Forodesine IV (Bcx-1777) Is Clinically Active in Relapsed/Refractory T-Cell Leukemia: Results of a Phase II Study (Interim Report).
R. Furman
,
Lia Gore
,
F. Ravandi
,
D. Hoelzer
2006
Corpus ID: 78771135
Background: Forodesine, a potent, rationally designed purine nucleoside phosphorylase inhibitor, has shown clinical activity in T…
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2006
2006
Oral Forodesine (Bcx-1777) Is Clinically Active in Refractory Cutaneous T-Cell Lymphoma: Results of a Phase I/II Study.
M. Duvic
,
A. Forero-Torres
,
F. Foss
,
Elsie A. Olsen
,
Y. Kim
2006
Corpus ID: 78419246
Background: Forodesine is a potent, rationally designed purine nucleoside phosphorylase (PNP) inhibitor that is orally…
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Highly Cited
2005
Highly Cited
2005
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine).
V. Gandhi
,
J. Kilpatrick
,
+9 authors
D. Thomas
Blood
2005
Corpus ID: 278201
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme…
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Highly Cited
2003
Highly Cited
2003
Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.
S. Bantia
,
S. Ananth
,
C. Parker
,
LaShun L Horn
,
Ramanda Upshaw
International immunopharmacology
2003
Corpus ID: 45577292
Purine nucleoside phosphorylase (PNP) deficiency in humans produces a relatively selective depletion of T cells. BCX-1777 is a…
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2003
2003
Arsenate reduction in human erythrocytes and rats--testing the role of purine nucleoside phosphorylase.
B. Németi
,
I. Csanaky
,
Z. Gregus
Toxicological sciences : an official journal of…
2003
Corpus ID: 25415058
Reduction of the pentavalent arsenate (AsV) to the thiol-reactive arsenite (AsIII) toxifies this environmentally prevalent form…
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2002
2002
Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777.
Shanta Banti
,
P. J. Miller
,
+4 authors
J. Sandhu
International immunopharmacology
2002
Corpus ID: 4584104
Purine nucleoside phosphorylase (PNP) deficiency in humans produces a relatively selective depletion of T-cells. Inhibitors of…
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Highly Cited
2001
Highly Cited
2001
Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent.
S. Bantia
,
P. J. Miller
,
+7 authors
J. Sandhu
International immunopharmacology
2001
Corpus ID: 39841046
Patients with purine nucleoside phosphorylase (PNP) deficiency present a selective T-cell immunodeficiency. Inhibitors of PNP are…
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