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imiglucerase

Known as: imiglucerase [Chemical/Ingredient] 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND The mainstay of treatment for Gaucher's disease type 1 is alternate-week infusion of enzyme replacement therapy (ERT… Expand
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2013
2013
Velaglucerase alfa is a glucocerebrosidase produced by gene activation technology in a human fibroblast cell line (HT‐1080), and… Expand
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Review
2012
Review
2012
  • P. Deegan, T. Cox
  • Drug design, development and therapy
  • 2012
  • Corpus ID: 16423982
The scientific and therapeutic development of imiglucerase (Cerezyme®) by the Genzyme Corporation is a paradigm case for a… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND In Gaucher disease (GD), acid-β-glucosidase (GBA1) gene mutations result in defective glucocerebrosidase and variable… Expand
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  • table 4
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Highly Cited
2010
Highly Cited
2010
Gaucher disease is the first lysosomal disorder for which clinically effective enzyme replacement therapy has been introduced… Expand
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Highly Cited
2008
Highly Cited
2008
Progressive skeletal disease accounts for some of the most debilitating complications of type 1 Gaucher disease. In this 48‐month… Expand
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Highly Cited
2008
Highly Cited
2008
To assess the extent to which patients with type 1 Gaucher disease (GD1) receiving individualized enzyme replacement therapy with… Expand
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Highly Cited
2007
Highly Cited
2007
The effect of ERT with imiglucerase on BMD in type 1 GD was studied using BMD data from the International Collaborative Gaucher… Expand
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2000
2000
We have recently demonstrated that incubation of cultured rat hippocampal neurons with conduritol β-epoxide (CBE), an inhibitor… Expand
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Highly Cited
1995
Highly Cited
1995
Gaucher's disease, the most common sphingolipidosis, is caused by deficiency of the lysosomal enzyme glucocerebrosidase. Therapy… Expand
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