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Miglustat

Known as: Miglustatum, N-Butyl deoxynojirimycin, 1,5-(butylimino)-1,5-dideoxy-D-glucitol 
A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (4)

1-DeoxynojirimycinAnti-HIV AgentsEnzyme InhibitorsGlycoside Hydrolase Inhibitors
GLUCOSYLCERAMIDASEMiglustat 100 MG Oral CapsuleMiglustat 100 MG Oral Capsule [Zavesca]analogs & derivatives

Narrower (3)

OGT 918SC-48334Zavesca

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Control of the optical properties of a star copolymer with a hyperbranched conjugated polymer core and poly(ethylene glycol) arms by self-assembly.
A self-assembly approach to tuning the optical properties of a star copolymer is reported herein. The star copolymer HCP-star-PEG… 
2007
2007
Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment
SummaryObjective: Fabry disease results from α-gala- ctosidase A deficiency and is characterized by the lysosomal accumulation of… 
2007
2007
N‐butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice
Aim:  To determine the mechanism of weight loss caused by high doses of N‐butyldeoxynojirimycin (NB‐DNJ) in healthy lean and… 
2003
2003
The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs
Conversion of ceramide, a putative mediator of anticancer drug‐induced apoptosis, into glucosylceramide, by the action of… 
Review
2003
Review
2003
Miglustat. Oxford GlycoSciences/Actelion.
Oxford GlycoSciences and Actelion have developed and launched miglustat (OGT-918; Vevesca; Zavesca) for the treatment of type 1… 
2002
2002
pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells.
Review
2001
Review
2001
Agents for the treatment of glycosphingolipid storage disorders.
We have developed a series of inhibitors of glucosylceramide synthase that are structurally based on the parent compound D-threo… 
2000
2000
Influence of the novel urease inhibitor N-(n-butyl) thiophosphoric triamide on ruminant nitrogen metabolism: I. In vitro urea kinetics and substrate digestion.
Two in vitro digestion experiments were conducted to evaluate the influence of the novel urease inhibitor N-(n-butyl… 
Highly Cited
1996
Highly Cited
1996
Induction of glucosylceramide synthase by synthase inhibitors and ceramide.
1990
1990
Attenuation of HIV-1 infectivity by an inhibitor of oligosaccharide processing.
A series of inhibitors of trimming glucosidases and mannosidases were examined for antiviral activity toward HIV-1. N-butyl… 
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