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Miglustat

Known as: Miglustatum, N-Butyl deoxynojirimycin, 1,5-(butylimino)-1,5-dideoxy-D-glucitol 
A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (4)

1-DeoxynojirimycinAnti-HIV AgentsEnzyme InhibitorsGlycoside Hydrolase Inhibitors
GLUCOSYLCERAMIDASEMiglustat 100 MG Oral CapsuleMiglustat 100 MG Oral Capsule [Zavesca]analogs & derivatives

Narrower (3)

OGT 918SC-48334Zavesca

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The Pharmacological Chaperone N-butyldeoxynojirimycin Enhances Enzyme Replacement Therapy in Pompe Disease Fibroblasts
In spite of the progress in the treatment of lysosomal storage diseases (LSDs), in some of these disorders the available… 
Highly Cited
2007
Highly Cited
2007
A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.
Dengue fever is an emerging arboviral disease for which no vaccine or antiviral treatment exists and that causes thousands of… 
Highly Cited
2005
Highly Cited
2005
Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles.
Highly Cited
2002
Highly Cited
2002
Antiviral Effects of an Iminosugar Derivative on Flavivirus Infections
ABSTRACT Endoplasmic reticulum (ER) α-glucosidase inhibitors, which block the trimming step of N-linked glycosylation, have been… 
Highly Cited
2001
Highly Cited
2001
Critical role for glycosphingolipids in Niemann-Pick disease type C
Highly Cited
2001
Highly Cited
2001
Assembly and Maturation of the Flavivirus Kunjin Virus Appear To Occur in the Rough Endoplasmic Reticulum and along the Secretory Pathway, Respectively
ABSTRACT The intracellular assembly site for flaviviruses in currently not known but is presumed to be located within the lumen… 
Highly Cited
2000
Highly Cited
2000
Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation.
We used a potent inhibitor of glucosylceramide synthase to test whether substrate deprivation could lower globotriaosylceramide… 
Highly Cited
1995
Highly Cited
1995
The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding
The alpha-glucosidase inhibitor N-butyldeoxynojirimycin (NB-DNJ) is a potent inhibitor of human immunodeficiency virus (HIV… 
Highly Cited
1994
Highly Cited
1994
Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.
The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I… 
Highly Cited
1988
Highly Cited
1988
Aminosugar derivatives as potential anti-human immunodeficiency virus agents.
Recent data suggest that aminosugar derivatives which inhibit glycoprotein processing have potential anti-human immunodeficiency… 
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