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GLUCOSYLCERAMIDASE

Known as: Lysosomal Glucocerebrosidase, beta Glucocerebrosidase, D-Glucosyl-N-Acylsphingosine Glucohydrolase 
A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Parkinson disease (PD) treatment options have conventionally focused on dopamine replacement and provision of symptomatic relief… Expand
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Review
2019
Review
2019
James Parkinson first described the motor symptoms of the disease that took his name over 200 years ago. While our knowledge of… Expand
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Highly Cited
2012
Highly Cited
2012
Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor for developing Parkinson disease (PD). We… Expand
Review
2009
Review
2009
Research in Parkinson's disease (PD) genetics has been extremely prolific over the past decade. More than 13 loci and 9 genes… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND A clinical association has been reported between type 1 Gaucher's disease, which is caused by a glucocerebrosidase… Expand
Highly Cited
2000
Highly Cited
2000
BACKGROUND Current treatment for Gaucher's disease involves administration of intravenous glucocerebrosidase to degrade… Expand
Review
2000
Review
2000
Plants have considerable potential for the production of biopharmaceutical proteins and peptides because they are easily… Expand
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Highly Cited
1994
Highly Cited
1994
Gaucher disease (GD; glucosylceramidosis) is caused by a deficient activity of the enzyme glucocerebrosidase (GC). Clinical… Expand
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Highly Cited
1991
Highly Cited
1991
BACKGROUND AND METHODS Gaucher's disease, the most prevalent of the sphingolipid storage disorders, is caused by a deficiency of… Expand