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GLUCOSYLCERAMIDASE

Known as: Lysosomal Glucocerebrosidase, beta Glucocerebrosidase, D-Glucosyl-N-Acylsphingosine Glucohydrolase 
A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (3)

AbcertinGBA1 protein, zebrafishimiglucerase
Acid beta glucosidase:CCnc:Pt:Bld.dot:QnAcid beta glucosidase:CCnt:Pt:Fibroblasts:QnAcid beta glucosidase:CCnt:Pt:WBC:QnAcid beta glucosidase:CCnt:Pt:XXX:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Analysis of the beta-glucocerebrosidase gene in Czech and Slovak Gaucher patients: mutation profile and description of six novel mutant alleles.
The aim of this study was to characterize the spectrum of 13-glucocerebrosidase gene mutations in Czech and Slovak Gaucher… 
Highly Cited
1994
Highly Cited
1994
Correction of the enzyme deficiency in hematopoietic cells of Gaucher patients using a clinically acceptable retroviral supernatant transduction protocol.
Gaucher disease is a lysosomal storage disorder caused by a deficiency of the enzyme glucocerebrosidase (GC), and is an excellent… 
Review
1993
Review
1993
Gaucher disease as a paradigm of current issues regarding single gene mutations of humans.
Gaucher disease is a glycolytic storage disease caused by a deficiency in activity of the catabolic enzyme glucocerebrosidase… 
1990
1990
Influence of Endogenous Cytokinins on Reverse Mobilization in Cotyledons of Cicer arietinum L: Reproduction of Endogenous Levels of Total Cytokinins, Zeatin, Zeatin Riboside, and Their Corresponding…
The embryonic axis plays an essential role in the mobilization of the main reserves of the cotyledons of seeds of Cicer arietinum… 
Highly Cited
1989
Highly Cited
1989
Comparison of RNase A, a chemical cleavage and GC-clamped denaturing gradient gel electrophoresis for the detection of mutations in exon 9 of the human acid beta-glucosidase gene.
Gaucher disease (GD), which results from mutations in the human acid beta-glucosidase (beta-Glc) gene, was used as a model system… 
1988
1988
Glycosylation and processing of high levels of active human glucocerebrosidase in invertebrate cells using a baculovirus expression vector.
A human cDNA containing the complete coding region for the lysosomal glycoprotein glucocerebrosidase (EC 3.2.1.45) was introduced… 
Highly Cited
1985
Highly Cited
1985
The subcellular localization of soluble and membrane-bound lysosomal enzymes in I-cell fibroblasts: a comparative immunocytochemical study.
Using electron microscopic immunocytochemistry with gold probes, we have studied the localization of acid alpha-glucosidase, N… 
Highly Cited
1984
Highly Cited
1984
Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases
1983
1983
Modification of subunit interaction in membrane‐bound acid β‐glucosidase from Gaucher disease
Highly Cited
1976
Highly Cited
1976
Solubilization of glucocerebrosidase from human placenta and demonstration of a phospholipid requirement for its catalytic activity.
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