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idrapril

Known as: 2-(((2-(hydroxyamino)-2-oxoethyl)methylamino)carbonyl)cyclohexanecarboxylic acid, 2-((N-(2-hydroxyamino-2-oxoethyl)-N-methylamino)carbonyl)cyclohexane-1-carboxylic acid, Cyclohexanecarboxylic acid, 2-(((2-(hydroxyamino)-2-oxoethyl)methylamino)carbonyl)-, (1S-cis)- 
A hydroxamic, non-amino acid derivative angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Idrapril competitively binds to… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Cyclohexanecarboxylic AcidsHydroxylamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes.
Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of recurrent myocardial infarction in patients with left… 
1997
1997
Alteration of cytochrome P-450 isozymes by captopril and idrapril in hepatic and renal microsomes of normotensive and spontaneously hypertensive rats.
To examine the effects of angiotensin-converting enzyme (ACE)inhibitors such as captopril and idrapril on the P-450 system, these… 
1996
1996
Effects of a new angiotensin-converting enzyme inhibitor (idrapril) in rats with left ventricular dysfunction after myocardial infarction.
We evaluated the effects of a new angiotensin-converting enzyme (ACE) inhibitor (idrapril) in terms of hemodynamics and… 
1996
1996
Reductive metabolism and its role in the disposition of the hydroxamic angiotensin-converting enzyme inhibitor idrapril calcium in rat.
1. The metabolism of 14C-idrapril calcium, the prototype of a new class of angiotensin-converting enzyme inhibitors, was studied… 
1995
1995
Effects of Idrapril Calcium on Tissue Angiotensin‐Converting Enzyme in Rats
Summary: Tissue angiotensin-converting enzyme (ACE) inhibition was measured in rats after single intravenous (i.v.) and oral (p.o… 
1994
1994
Pharmacokinetics and biochemical efficacy of idrapril calcium, a novel ACE inhibitor, after multiple oral administration in humans.
The pharmacokinetic profile and biochemical efficacy of idrapril calcium, a novel angiotensin converting enzyme (ACE) inhibitor… 
1994
1994
Angiotensin-converting enzyme inhibition by hydroxamic zinc-binding idrapril in humans.
The new angiotensin-converting enzyme (ACE) inhibitor idrapril acts by binding the catalytically important zinc ion to a… 
1994
1994
High-performance liquid chromatographic method with electrochemical detection for the determination of idrapril, a novel angiotensin-converting enzyme inhibitor, in biological matrices.
1993
1993
Pharmacokinetics and pharmacodynamics of idrapril in rats, dogs, and humans.
Idrapril is the prototype of a new class of angiotensin converting enzyme (ACE) inhibitors. Its pharmacokinetics and… 
1992
1992
Pharmacology of Idrapril: A New Class of Angiotensin Converting Enzyme Inhibitors
Summary: Idrapril is the prototype of a new chemical class of angiotensin converting enzyme (ACE) inhibitors, the hydroxamic non… 
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