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Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability.
TLDR
The observation that Ang II induces IL-6 and their colocalization with the AT(1) receptor and ACE is consistent with the notion that the RAS may contribute to inflammatory processes within the vascular wall and to the development of acute coronary syndromes.
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Specific measurement of angiotensin metabolites and in vitro generated angiotensin II in plasma.
TLDR
In eight seated normal subjects treated for 4 days with enalapril, angiotensin II metabolites tended to decrease during the 4 postdrug hours, however, their cumulated concentration in relation to octapeptide increased from 54 to 163% on Day 1 and from 62 to 103% on Days 4.
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Renal effects of selective cyclooxygenase‐2 inhibition in normotensive salt‐depleted subjects
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Bradykinin and the pathophysiology of angioedema.
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Aldosterone Synthase Inhibitor Ameliorates Angiotensin II–Induced Organ Damage
TLDR
Aldosterone plays a key role in the pathogenesis of Ang II–induced organ damage and the present results show that aldosterone produced in the adrenals is the main source of cardiac ald testosterone.
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Release of Bradykinin and Expression of Kinin B2 Receptors in the Brain: Role for Cell Death and Brain Edema Formation After Focal Cerebral Ischemia in Mice
TLDR
The current results show that bradykinin is produced in the brain, kinin B2 receptors are upregulated on dying cells, and B1 receptors are involved in cell death and brain edema formation after experimental stroke.
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Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers.
TLDR
TCV-116 appears to be a well-tolerated, orally active, potent, and long-lasting antagonist of Ang II in men.
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Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men.
TLDR
Pioglitazone stimulates plasma renin activity and favors sodium retention and weight gain in healthy volunteers, which could contribute to the development of edema in some subjects treated with glitazones.
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Renal neurohormonal and vascular responses to dynamic exercise in humans.
Effects of graded supine dynamic exercise (30, 60, and 80-90% of maximal physical capacity, i.e., work loads of 69, 132, and 188 W) on renal vascular resistance (RVR); renal sympathetic nerve…
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Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity
TLDR
Obesity-induced endothelial dysfunction depends on the ‘endothelial’ MR and is mediated by an imbalance of oxidative stress-modulating mechanisms, therefore, MR antagonists may represent an attractive therapeutic strategy in the increasing population of obese patients to decrease vascular dysfunction and subsequent atherosclerotic complications.
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