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icaritin

National Institutes of Health

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Flavonoids

Papers overview

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2019
2019
Analgesic, anti-inflammatory and sedative/hypnotic effects of Icaritin, and its effect on chloride influx in mouse brain cortical cells.
Inflammation and insomnia are medical problems that may severely affect work and health, thereby necessitating strategies for… 
2018
2018
A multicenter, single arm phase II trial of a small molecule immune-modulator icaritin: Safety, overall survival, immune dynamics, and PD-L1 expression in advanced hepatocellular carcinoma.
4077Background: HCC was characterized with high heterogeneity and immune “tolerogenic”. Despite of immune checkpoint inhibitors… 
2017
2017
Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro
ObjectiveIcaritin, one effective metabolite of Herba Epimedii-derived flavonoid icariin, has a strong osteogenic activity… 
2014
2014
The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats
Central-icaritin (CIT) is a flavonoid aglycone first discovered in our laboratory, which is an isomeric aglycone of icaritin (IT… 
2013
2013
Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair
This study was designed to develop a bioactive scaffold to enhance bone defect repair in steroid‐associated osteonecrosis (SAON… 
2012
2012
Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair
This study was designed to develop a bioactive scaffold to enhance bone defect repair in steroid-associated osteonecrosis (SAON… 
2010
2010
Icaritin induces growth inhibition and apoptosis of human prostatic smooth muscle cells in an estrogen receptor-independent manner
Icaritin has selective estrogen receptor (ER) modulating activity. ERs are expressed in the prostate stroma, and estrogens have… 
2010
2010
Preparation of icaritin phytosomes and their solid dispersions.
Objective To optimize preparation techniques for icaritin phytosomes and explore their solid dispersions to increase the… 
2000
2000
Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional…
In this study, we demonstrated that hypoxia/reoxygenation (H/R) induced an injury in gap junctional intercellular communication… 
2000
2000
Screening of anti-hypoxia/reoxygenation agents by an in vitro model. Part 1: Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein…
Protein tyrosine kinase (PTK) signaling pathways play important roles in ischemia/reperfusion (I/R) or hypoxia/reoxygenation (H/R… 
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