• Publications
  • Influence
Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblasts Revealed by Microarray and Bioinformatics*
Parathyroid hormone (PTH) binds to its receptor PTH1R (parathyroid hormone 1 receptor) in osteoblastic cells to regulate bone remodeling and calcium homeostasis. While prolonged exposure to PTHExpand
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Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation*
Parathyroid hormone (PTH) is the major mediator of calcium homeostasis and bone remodeling and is now known to be an effective drug for osteoporosis treatment. Yet the mechanisms responsible for itsExpand
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Epimedium‐Derived Phytoestrogen Flavonoids Exert Beneficial Effect on Preventing Bone Loss in Late Postmenopausal Women: A 24‐Month Randomized, Double‐Blind and Placebo‐Controlled Trial
Epimedium brevicornum maxim, a nonleguminous medicinal plant, has been found to be rich in phytoestrogen flavonoids. Results from a 24‐month randomized double‐blind placebo‐controlled clinical trialExpand
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Consilience of genetics and archaeobotany in the entangled history of rice
Major leaps forward in understanding rice both in genetics and archaeology have taken place in the past decade or so—with the publication of full draft genomes for indica and japonica rice, on theExpand
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Transcription Regulation of ompF and ompC by a Single Transcription Factor, OmpR*
The ompF and ompC genes of Escherichia coli are reciprocally regulated by a single transcription factor, phosphorylated OmpR (OmpR-P), depending upon medium osmolarity. This regulation involvesExpand
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Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.
The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV. AMD3100 has been shown to be a CXCR4 receptor antagonist,Expand
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Determination of Dual Effects of Parathyroid Hormone on Skeletal Gene Expression in Vivo by Microarray and Network Analysis*
Parathyroid hormone (PTH) stimulates bone formation when injected daily but causes severe bone loss with continuous infusion. The mechanism of its paradoxical effects is still elusive. In this study,Expand
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A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy
Metabolic skeletal disorders associated with impaired bone formation are a major clinical challenge. One approach to treat these defects is to silence bone-formation–inhibitory genes by smallExpand
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Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
CC chemokine receptor 2 (CCR2) is one of 19 members of the chemokine receptor subfamily of human class A G-protein-coupled receptors. CCR2 is expressed on monocytes, immature dendritic cells, andExpand
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Targeting the osteosarcoma cancer stem cell
  • V. Siclari, L. Qin
  • Medicine
  • Journal of orthopaedic surgery and research
  • 27 October 2010
Osteosarcoma is the most common type of solid bone cancer and the second leading cause of cancer-related death in pediatric patients. Many patients are not cured by the current osteosarcoma therapyExpand
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