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hypusine

Known as: (+)-hypusine, (R)-N6-(4-amino-2-hydroxybutyl)-L-lysine, N(6)-(4-amino-2-hydroxybutyl)-L-lysine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lysine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Horizontal gene transfer and archaeal origin of deoxyhypusine synthase homologous genes in bacteria.
1997
1997
Interferon alpha2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells.
We previously found that interferon alpha2 recombinant (IFNalpha) increases the expression of epidermal growth factor receptor… 
Highly Cited
1996
Highly Cited
1996
Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae
Highly Cited
1993
Highly Cited
1993
The HYP2 gene of Saccharomyces cerevisiae is essential for aerobic growth: characterization of different isoforms of the hypusine-containing protein Hyp2p and analysis of gene disruption mutants
In Saccharomyces cerevisiae, hypusine-containing proteins are encoded by two closely related genes, HYP1 and HYP2, which are… 
Highly Cited
1992
Highly Cited
1992
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.
The effects of inhibition of the capacity to form spermidine and spermine on cell growth were investigated using murine leukaemia… 
1991
1991
The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes.
Highly Cited
1990
Highly Cited
1990
The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D.
Highly Cited
1989
Highly Cited
1989
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Eukaryotic translation initiation factor 4D (eIF-4D) is the only protein known to contain the amino acid, hypusine [N epsilon-(4… 
1988
1988
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Highly Cited
1986
Highly Cited
1986
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.
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