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hypothalamic-pituitary-adrenal axis

Known as: HPA, hypothalamic pituitary adrenal (HPA) axis, hypothalamic pituitary adrenal axis 
National Institutes of Health

Related topics

Related topics

10 relations
Adrenal GlandsPituitary Glandbiological adaptation to stressregulatory loop

Broader (2)

Neurosecretory Systemsendocrine pathways and axes

Narrower (3)

Pituitary-Adrenal Function TestsPituitary-Adrenal Systemhypothalamic pituitary axis

Papers overview

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Highly Cited
2009
Highly Cited
2009
Neonatal lipopolysaccharide and adult stress exposure predisposes rats to anxiety-like behaviour and blunted corticosterone responses: Implications for the double-hit hypothesis
Highly Cited
2005
Highly Cited
2005
Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat.
Organizational effects of testosterone during a critical period of neonatal life have major irreversible effects on adult sexual… 
Highly Cited
2001
Highly Cited
2001
The Central Effects of Orexin‐A in the Hypothalamic‐Pituitary‐Adrenal Axis In Vivo and In Vitro in Male Rats
Orexin‐A is synthesized in the posterolateral hypothalamus and immunoreactive fibres project to many central nervous system… 
Highly Cited
2001
Highly Cited
2001
Dorsal and Ventral Medullary Catecholamine Cell Groups Contribute Differentially to Systemic Interleukin-1β-Induced Hypothalamic Pituitary Adrenal Axis Responses
Medial parvocellular paraventricular corticotropin-releasing hormone (mPVN CRH) cells are critical in generating hypothalamic… 
Highly Cited
1997
Highly Cited
1997
Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis.
The present study compared the effect of different modes of alcohol administration on the activity of the hypothalamic-pituitary… 
Highly Cited
1994
Highly Cited
1994
Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats.
Aging is frequently associated with changes in physiological and cognitive processes. Among these changes is a distinct… 
Review
1994
Review
1994
Immune system-central nervous system interactions: effect and immunomodulatory consequences of immune system mediators on the brain
A bidirectional circuit exists between the central nervous system and the immune system, since activation of the immune system… 
Highly Cited
1993
Highly Cited
1993
Hypothalamic pituitary adrenal function in the extremely low birth weight infant.
Extremely premature infants manifest clinical features suggestive of adrenal insufficiency. Yet, serum cortisol levels are… 
Highly Cited
1989
Highly Cited
1989
Single-dose ethanol administration activates the hypothalamic-pituitary-adrenal axis: exploration of the mechanism of action.
Activation of the hypothalamic-pituitary-adrenal axis (HPAA) by single-dose ethanol administration, which achieved moderately… 
Highly Cited
1987
Highly Cited
1987
Diminished responsiveness of the hypothalamic-pituitary-adrenal axis of the rat during exposure to prolonged stress: a pituitary-mediated mechanism.
Intact rats exposed to low or moderate intensity electroshocks for 3-5 h showed a marked increase in plasma ACTH levels 10 min… 
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