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hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The genetically polymorphic cytochrome P450 2C9 (CYP2C9) metabolizes many important drugs. Among them, phenytoin has been used as… Expand
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Highly Cited
2001
Highly Cited
2001
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… Expand
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Highly Cited
2000
Highly Cited
2000
To assess the effects of Ile359 to Leu359 change on CYP2C9-mediated metabolism, we performed site-directed mutagenesis and cDNA… Expand
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Highly Cited
2000
Highly Cited
2000
Formation of four oxidative metabolites from the anticonvulsant drug phenytoin (DPH) catalyzed by human liver microsomal… Expand
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Highly Cited
1998
Highly Cited
1998
Summary: Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19… Expand
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Highly Cited
1987
Highly Cited
1987
Phenytoin pharmacokinetics exhibit large intersubject differences and coinheritance of phenytoin metabolism with known drug… Expand
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1984
1984
We present a fully automated high-pressure liquid chromatographic (HPLC) assay for simultaneous quantitation of five… Expand
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Highly Cited
1983
Highly Cited
1983
Eight normal subjects were given 250 mg intravenous phenytoin alone and with 3‐day regimens of oral Cimetidine, 400 mg at bedtime… Expand
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1981
1981
Eight subjects were studied in a randomized crossover design to determine the effect of aluminum-magnesium hydroxide (AMH… Expand
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1980
1980
We describe a liquid-chromatographic assay for phenytoin and its para-hydroxylated metabolite, 5-(4-hydroxyphenyl)-5… Expand
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