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hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
National Institutes of Health

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3 relations

Broader (2)

DihydanPhenytoin
analogs & derivatives

Papers overview

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2001
2001
Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats.
Phenytoin, 5,5-diphenylhydantoin, is a widely used anticonvulsant agent with a variety of toxicities, including drug interactions… 
2000
2000
Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal… 
1997
1997
Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese.
AIMS The aim of this study was to clarify whether phenytoin (PHT) stereoselective hydroxylation cosegregates with (S)-mephenytoin… 
1996
1996
Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients.
This study examined the relationships between plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl)-5… 
1987
1987
Simultaneous measurement of phenobarbital, carbamazepine, phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in serum by high-performance liquid chromatography.
A rapid, highly sensitive high-performance liquid chromatographic method has been developed for the determination of… 
1982
1982
Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteins.
1981
1981
Effect of Antacids on Phenytoin Bioavailability
Eight subjects were studied in a randomized crossover design to determine the effect of aluminum-magnesium hydroxide (AMH… 
1980
1980
Liquid-chromatographic method for simultaneous determination of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in plasma and urine.
We describe a liquid-chromatographic assay for phenytoin and its para-hydroxylated metabolite, 5-(4-hydroxyphenyl)-5… 
1976
1976
Mass fragmentographic determination of diphenylhydantoin and its main metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, in human plasma.
1975
1975
Absolute configuration of the major metabolite of 5,5-diphenylhydantoin, 5-(4'-hydroxyphenyl)-5-phenylhydantoin.
Chemical conversions, optical comparisons, and chiroptical measurements (CD) were employed to determine the absolute… 
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