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hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
National Institutes of Health

Papers overview

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2007
2007
5-(4′-Hydroxyphenyl)-5-phenylhydantoin (4′-HPPH), a major metabolite of phenytoin in human, is exclusively metabolized to a… Expand
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Highly Cited
2005
Highly Cited
2005
The genetically polymorphic cytochrome P450 2C9 (CYP2C9) metabolizes many important drugs. Among them, phenytoin has been used as… Expand
Highly Cited
2001
Highly Cited
2001
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… Expand
Highly Cited
2000
Highly Cited
2000
To assess the effects of Ile359 to Leu359 change on CYP2C9-mediated metabolism, we performed site-directed mutagenesis and cDNA… Expand
Highly Cited
2000
Highly Cited
2000
Formation of four oxidative metabolites from the anticonvulsant drug phenytoin (DPH) catalyzed by human liver microsomal… Expand
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Highly Cited
1998
Highly Cited
1998
Summary: Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19… Expand
Highly Cited
1997
Highly Cited
1997
The cytochrome P450-dependent covalent binding of radiolabel derived from phenytoin (DPH) and its phenol and catechol metabolites… Expand
Highly Cited
1987
Highly Cited
1987
Phenytoin pharmacokinetics exhibit large intersubject differences and coinheritance of phenytoin metabolism with known drug… Expand
1980
1980
We describe a liquid-chromatographic assay for phenytoin and its para-hydroxylated metabolite, 5-(4-hydroxyphenyl)-5… Expand
1975
1975
Chemical conversions, optical comparisons, and chiroptical measurements (CD) were employed to determine the absolute… Expand