hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2015
02419752015

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
From the Center for Clinical Epidemiology & Biostatistics and the Department of Biostatistics & Epidemiology, University of… (More)
  • table I
Is this relevant?
2005
2005
The genetically polymorphic cytochrome P450 2C9 (CYP2C9) metabolizes many important drugs. Among them, phenytoin has been used as… (More)
Is this relevant?
2002
2002
In humans, orally administered phenytoin, 5,5-diphenylhydantoin, is mainly excreted as 5-(4'-hydroxyphenyl)-5-phenylhydantoin (4… (More)
Is this relevant?
2001
2001
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… (More)
Is this relevant?
2001
2001
Phenytoin, 5,5-diphenylhydantoin, is a widely used anticonvulsant agent with a variety of toxicities, including drug interactions… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2000
Highly Cited
2000
To assess the effects of Ile359 to Leu359 change on CYP2C9-mediated metabolism, we performed site-directed mutagenesis and cDNA… (More)
Is this relevant?
2000
2000
Formation of four oxidative metabolites from the anticonvulsant drug phenytoin (DPH) catalyzed by human liver microsomal… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
1998
1998
PURPOSE The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19 on the… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • figure 2
Is this relevant?
1997
1997
The cytochrome P450-dependent covalent binding of radiolabel derived from phenytoin (DPH) and its phenol and catechol metabolites… (More)
Is this relevant?
1997
1997
The phenytoin hydroxylation index was studied in 122 unrelated Caucasian volunteers. Following a 100 mg oral dose of phenytoin… (More)
Is this relevant?