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hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
National Institutes of Health

Papers overview

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2007
2007
5-(4′-Hydroxyphenyl)-5-phenylhydantoin (4′-HPPH), a major metabolite of phenytoin in human, is exclusively metabolized to a… 
Highly Cited
2005
Highly Cited
2005
The genetically polymorphic cytochrome P450 2C9 (CYP2C9) metabolizes many important drugs. Among them, phenytoin has been used as… 
Highly Cited
2001
Highly Cited
2001
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… 
Highly Cited
2000
Highly Cited
2000
To assess the effects of Ile359 to Leu359 change on CYP2C9-mediated metabolism, we performed site-directed mutagenesis and cDNA… 
Highly Cited
2000
Highly Cited
2000
Formation of four oxidative metabolites from the anticonvulsant drug phenytoin (DPH) catalyzed by human liver microsomal… 
Highly Cited
1998
Highly Cited
1998
Summary: Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C9 and 2C19… 
Highly Cited
1987
Highly Cited
1987
Phenytoin pharmacokinetics exhibit large intersubject differences and coinheritance of phenytoin metabolism with known drug… 
1981
1981
Eight subjects were studied in a randomized crossover design to determine the effect of aluminum-magnesium hydroxide (AMH… 
1980
1980
We describe a liquid-chromatographic assay for phenytoin and its para-hydroxylated metabolite, 5-(4-hydroxyphenyl)-5…