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hydroxyphenytoin

Known as: 5-(4'-hydroxyphenyl)-5-phenylhydantoin, 4'-HPPH, 5-(4-hydroxyphenyl)-5-phenylhydantoin 
National Institutes of Health

Related topics

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3 relations

Broader (2)

DihydanPhenytoin
analogs & derivatives

Papers overview

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Highly Cited
2001
Highly Cited
2001
Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… 
1994
1994
Simultaneous Determination of Felbamate, Primidone, Phenobarbital, Carbamazepine, Two Carbamazepine Metabolites, Phenytoin, and One Phenytoin Metabolite in Human Plasma by High‐Performance Liquid…
Summary An isocratic liquid-chromatographic method employing one extraction step has been developed for the quantitation of five… 
Highly Cited
1987
Highly Cited
1987
Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans.
Phenytoin pharmacokinetics exhibit large intersubject differences and coinheritance of phenytoin metabolism with known drug… 
Highly Cited
1983
Highly Cited
1983
Dose‐dependent effect of cimetidine on phenytoin kinetics
Eight normal subjects were given 250 mg intravenous phenytoin alone and with 3‐day regimens of oral Cimetidine, 400 mg at bedtime… 
1982
1982
Evidence for an arene oxide-NIH shift pathway in the metabolic conversion of phenytoin to 5-(4-hydroxyphenyl)-5-phenylhydantoin in the rat and in man.
To determine whether the hydroxylation of 5,5-diphenylhydantoin (DPH) to 5-(4-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) occurs by… 
1982
1982
Mutagenicity of diphenylhydantoin and some of its metabolites towards salmonella typhimurium strains.
1981
1981
Effect of Antacids on Phenytoin Bioavailability
Eight subjects were studied in a randomized crossover design to determine the effect of aluminum-magnesium hydroxide (AMH… 
1980
1980
Liquid-chromatographic method for simultaneous determination of phenytoin and 5-(4-hydroxyphenyl)-5-phenylhydantoin in plasma and urine.
We describe a liquid-chromatographic assay for phenytoin and its para-hydroxylated metabolite, 5-(4-hydroxyphenyl)-5… 
1979
1979
Plasma levels and renal excretion of phenytoin and its metabolites in patients with renal failure
Phenytoin (DPH) and its two major metabolites, conjugated and unconjugated 5‐(4‐hydroxyphenyl)‐5‐phenylhydantoin (4‐OH‐DPH), have… 
1975
1975
Absolute configuration of the major metabolite of 5,5-diphenylhydantoin, 5-(4'-hydroxyphenyl)-5-phenylhydantoin.
Chemical conversions, optical comparisons, and chiroptical measurements (CD) were employed to determine the absolute… 
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