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Phenytoin

Known as: Phenytoin [Chemical/Ingredient], Phentytoin, Fenitoina 
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic… 
National Institutes of Health

Related topics

Related topics

42 relations
2 ML Fosphenytoin sodium 75 MG/ML InjectionAntiepileptic AgentsCYP2C19 protein, humanCYP2C9 protein, human

Narrower (11)

2-cyanoguanidinophenytoin3-(hydroxymethyl)phenytoin3-pentanoyl-5,5-diphenylhydantoinEpamin

Broader (4)

AnticonvulsantsCytochrome P-450 CYP1A2 InducersHydantoin derivative anticonvulsantVoltage-Gated Sodium Channel Blockers

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Life‐cycle exposure of fathead minnows (Pimephales promelas) to an ethinylestradiol concentration below 1 ng/L reduces egg fertilization success and demasculinizes males
Forty‐eight hours after fertilization, fathead minnow (Pimephales promelas) eggs were exposed to the synthetic estrogen 17… 
Review
2003
Review
2003
Tacrolimus: a further update of its use in the management of organ transplantation.
UNLABELLED Extensive clinical use has confirmed that tacrolimus (Prograf) is a key option for immunosuppression after… 
Review
1999
Review
1999
Hippocampal Remodeling and Damage by Corticosteroids: Implications for Mood Disorders
Highly Cited
1997
Highly Cited
1997
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold
Highly Cited
1994
Highly Cited
1994
Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.
The anticonvulsant phenytoin inhibited Na+ currents in rat hippocampal neurons with a potency that increased dramatically at… 
Highly Cited
1994
Highly Cited
1994
Na+ channels must deactivate to recover from inactivation
Review
1990
Review
1990
Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.
s, 18th International Epilepsy Congress, p. 90, New Delhi, India, 1989a. KALVIAINEN, R., SIvENIUS, J., YLINEN, A., AND RIEKKINEN… 
Highly Cited
1977
Highly Cited
1977
Dynamic structure of lipid bilayers studied by nanosecond fluorescence techniques.
Molecular motions in liposomes of dipalmitoyl-phosphatidylcholine (DPPC) were studied by nanosecond fluorescence techniques. As a… 
Review
1976
Review
1976
Letter: Enzymatic determination of cholesterol in high-density lipoprotein fractions prepared by polyanion precipitation.
In the recent tabulation of effects of drugs on clinical laboratory tests by Young et al. (1), two drugs are shown to increase… 
Highly Cited
1971
Highly Cited
1971
Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function.
Abstract The protein binding of diphenylhydantoin (DPH) and desmethylimipramine (DMI) was measured in plasma from azotemic and… 
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