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hydrogen peroxide biosynthetic process

Known as: hydrogen peroxide biosynthesis, hydrogen peroxide formation, H2O2 biosynthetic process 
The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
0102019462016

Papers overview

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Highly Cited
2011
Highly Cited
2011
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4.
In contrast to the NADPH oxidases Nox1 and Nox2, which generate superoxide (O(2)(·-)), Nox4 produces hydrogen peroxide (H(2)O(2… (More)
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Highly Cited
2002
Highly Cited
2002
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression.
Receptor-stimulated generation of reactive oxygen species (ROS) has been shown to regulate signal transduction, and previous… (More)
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Highly Cited
1999
Highly Cited
1999
Surfactant protein-A enhances respiratory syncytial virus clearance in vivo.
To determine the role of surfactant protein-A(SP-A) in antiviral host defense, mice lacking SP-A (SP-A-/-) were produced by… (More)
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Highly Cited
1997
Highly Cited
1997
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione.
Ceramide is a sphingolipid that is generated in the signaling of inflammatory cytokines such as tumor necrosis factor (TNF… (More)
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Highly Cited
1997
Highly Cited
1997
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation.
According to the state of mitochondrial respiration, the respiratory chain generates superoxide anions converted into hydrogen… (More)
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Highly Cited
1997
Highly Cited
1997
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis.
The key events implicated in ceramide-triggered apoptosis remain unknown. In this study we show that 25 microM C6-ceramide… (More)
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Highly Cited
1994
Highly Cited
1994
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse.
This study was conducted in order to test the concept that oxidative damage is associated with aging and may be a factor in the… (More)
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Highly Cited
1992
Highly Cited
1992
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
L-Arginine-derived nitric oxide (NO) acts as an inter- and intra-cellular signal molecule in many mammalian tissues including… (More)
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Highly Cited
1986
Highly Cited
1986
Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.
We have examined whether the toxic effects of homocysteine on cultured endothelial cells could result from the formation and… (More)
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Highly Cited
1975
Highly Cited
1975
Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues.
Mitochondria from beef heart, Morris hepatoma 3924A and Ehrlich ascites tumor (Lettré mutant) have been studied with respect to… (More)
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