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The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea, is mainly associated with the… Expand A host defense strategy against pathogens is the induction of cell death, thereby eliminating the pathogen's intracellular niche… Expand During λ infections, the holin S105 accumulates harmlessly in the membrane until, at an allele-specific time, suddenly triggering… Expand Bacteriophage biology has been the source of many of the fundamental paradigms of molecular genetics. The infective cycles of… Expand Two proteins, an endolysin and a holin, are essential for host lysis by bacteriophage. Endolysin is the term for muralytic… Expand
This chapter discusses the common properties of tailed phages and potential criteria for their… Expand The staphylococcal Panton-Valentine leukocidin (PVL) genes, [lukS-PV-lukF-PV], exist on the genome of a temperate bacteriophage… Expand During the lytic cycle of most bacteriophages, a phage-encoded peptidoglycan-degrading activity is elaborated. At least four… Expand The 22,163-bp genome of the lactococcal prolate-headed phage c2 was sequenced. Thirty-nine open reading frames (ORFs), early and… Expand Bacteriophage lysis involves at least two fundamentally different strategies. Most phages elaborate at least two proteins, one of… Expand