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holin activity

Known as: holin 
OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where… 
National Institutes of Health

Related topics

Related topics

3 relations
negative regulation of holin activitypathologic cytolysisprotein transporter activity

Papers overview

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2014
2014
Stable micron‐scale holes are a general feature of canonical holins
At a programmed time in phage infection cycles, canonical holins suddenly trigger to cause lethal damage to the cytoplasmic… 
Highly Cited
2007
Highly Cited
2007
Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB
PblA and PblB are prophage‐encoded proteins of Streptococcus mitis strain SF100 that mediate binding to human platelets. The… 
2005
2005
Functional analysis of the lysis genes of Staphylococcus aureus phage P68 in Escherichia coli.
Double-stranded DNA phages of both Gram-positive and Gram-negative bacteria typically use a holin-endolysin system to achieve… 
2004
2004
Whole-Genome DNA Array Analysis of the Response of Borrelia burgdorferi to a Bactericidal Monoclonal Antibody
ABSTRACT Identification and characterization of genes that contribute to infection with Borrelia burgdorferi and, of those, genes… 
2003
2003
Identification and Mutational Analysis of Bacteriophage PRD1 Holin Protein P35
ABSTRACT Holin proteins are phage-induced integral membrane proteins which regulate the access of lytic enzymes to host cell… 
Highly Cited
2000
Highly Cited
2000
Genetic and Biochemical Analysis of Dimer and Oligomer Interactions of the λ S Holin
ABSTRACT Bacteriophage λ uses a holin-endolysin system for host cell lysis. R, the endolysin, has muralytic activity. S, the… 
2000
2000
Characterization of Borrelia burgdorferiBlyA and BlyB Proteins: a Prophage-Encoded Holin-Like System
ABSTRACT The conserved cp32 plasmid family of Borrelia burgdorferi was recently shown to be packaged into a bacteriophage… 
1999
1999
The C-terminal sequence of the lambda holin constitutes a cytoplasmic regulatory domain.
The C-terminal domains of holins are highly hydrophilic and contain clusters of consecutive basic and acidic residues, with the… 
1998
1998
The lambda holin accumulates beyond the lethal triggering concentration under hyperexpression conditions.
Most bacteriophages terminate infection by creating lesions in the cytoplasmic membrane, which not only cause immediate cell… 
Highly Cited
1995
Highly Cited
1995
Primary structure and functional analysis of the lysis genes of Lactobacillus gasseri bacteriophage phi adh
The lysis genes of the Lactobacillus gasseri bacteriophage phi adh were isolated by complementation of a lambda Sam mutation in… 
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