histone deacetylase 3

Known as: HDAC3 enzyme, HD3, RPD3-2 
Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
05010019972017

Related topics

Related topics

12 relations
Chromatin Remodeling Complex and Coactivator PathwayChromatin Remodeling FactorDeacetylationEnzyme Gene
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Broader (1)

Histone Deacetylase

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
histone deacetylase 3
Transcriptional Regulation
Histone Deacetylase
chromatin remodeling
Deacetylation
Histone Deacetylation

Papers overview

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Highly Cited
2011
Highly Cited
2011
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone… (More)
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Highly Cited
2011
Highly Cited
2011
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.
Macrophages, a key cellular component of inflammation, become functionally polarized in a signal- and context-specific manner… (More)
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Highly Cited
2008
Highly Cited
2008
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.
Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety of disorders, including cancer… (More)
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Highly Cited
2008
Highly Cited
2008
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks.
Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression complexes recruited by the nuclear hormone… (More)
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Highly Cited
2004
Highly Cited
2004
Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.
The Runt domain transcription factor Runx2 (AML-3, and Cbfa1) is essential for osteoblast development, differentiation, and bone… (More)
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Highly Cited
2002
Highly Cited
2002
Functional domains of histone deacetylase-3.
Post-translational modifications of histones, in general, and acetylation/deacetylation, in particular, can dramatically alter… (More)
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Highly Cited
2001
Highly Cited
2001
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.
Repression of gene transcription is linked to regulation of chromatin structure through deacetylation of core histone amino… (More)
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Highly Cited
2000
Highly Cited
2000
The histone deacetylase-3 complex contains nuclear receptor corepressors.
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.
Transcription is controlled in part by the dynamic acetylation and deacetylation of histone proteins. The latter process is… (More)
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Highly Cited
1999
Highly Cited
1999
Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Gene expression is in part controlled by chromatin remodeling factors and the acetylation state of nucleosomal histones. The… (More)
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