histone deacetylase 3

Known as: HDAC3 enzyme, HD3, RPD3-2 
Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
05010019972017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Disruption of the circadian clock exacerbates metabolic diseases, including obesity and diabetes. We show that histone… (More)
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Highly Cited
2011
Highly Cited
2011
Macrophages, a key cellular component of inflammation, become functionally polarized in a signal- and context-specific manner… (More)
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Highly Cited
2008
Highly Cited
2008
Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety of disorders, including cancer… (More)
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Highly Cited
2008
Highly Cited
2008
Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression complexes recruited by the nuclear hormone… (More)
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Highly Cited
2004
Highly Cited
2004
The Runt domain transcription factor Runx2 (AML-3, and Cbfa1) is essential for osteoblast development, differentiation, and bone… (More)
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Highly Cited
2002
Highly Cited
2002
Post-translational modifications of histones, in general, and acetylation/deacetylation, in particular, can dramatically alter… (More)
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Highly Cited
2001
Highly Cited
2001
Repression of gene transcription is linked to regulation of chromatin structure through deacetylation of core histone amino… (More)
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Highly Cited
2000
Highly Cited
2000
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans… (More)
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Highly Cited
2000
Highly Cited
2000
Transcription is controlled in part by the dynamic acetylation and deacetylation of histone proteins. The latter process is… (More)
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Highly Cited
1999
Highly Cited
1999
Gene expression is in part controlled by chromatin remodeling factors and the acetylation state of nucleosomal histones. The… (More)
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