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histone deacetylase 3

Known as: HDAC3 enzyme, HD3, RPD3-2 
Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone… 
National Institutes of Health

Related topics

Related topics

12 relations
Chromatin Remodeling Complex and Coactivator PathwayChromatin Remodeling FactorDeacetylationEnzyme Gene

Broader (1)

Histone Deacetylase

Papers overview

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Highly Cited
2017
Highly Cited
2017
HDAC inhibitors enhance the immunotherapy response of melanoma cells
We focused on the ability of the pan-histone deacetylase (HDAC) inhibitors AR42 and sodium valproate to alter the immunogenicity… 
Highly Cited
2014
Highly Cited
2014
Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway
Increasing numbers of natural products have been found to possess anticancer effects. Nuclear factor erythroid-2-related factor-2… 
2011
2011
Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas
Transcriptional repressors such as nuclear receptor corepressors (NCORs) and class I histone deacetylases (HDACs) are considered… 
2007
2007
Bispyridinium dienes: histone deacetylase inhibitors with selective activities.
A novel synthetic route to the cyclostellettamines 1 using as the key step a microwave-mediated macrocyclic ring-closing… 
2007
2007
Promoter-dependent Effect of IKKα on NF-κB/p65 DNA Binding*
IKKα regulates many chromatin events in the nuclear phase of the NF-κB program, including phosphorylation of histone H3 and… 
2006
2006
Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.
In eukaryotic cells, the Ccr4-Not complex can regulate mRNA metabolism at various levels. Previously, we showed that promoter… 
2005
2005
The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.
In chronic myelocytic leukemia (CML) the activity of the Bcr-Abl tyrosine kinase is known to activate a number of molecular… 
Highly Cited
2005
Highly Cited
2005
Human THAP7 Is a Chromatin-associated, Histone Tail-binding Protein That Represses Transcription via Recruitment of HDAC3 and Nuclear Hormone Receptor Corepressor*
The identities of signal transducer proteins that integrate histone hypoacetylation and transcriptional repression are largely… 
2004
2004
Expression and functional characterization of recombinant human HDAC1 and HDAC3.
2002
2002
The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies
The MTG (Myeloid Translocation Gene) proteins are a family of novel transcriptional corepressors. We report that MTG16a, a… 
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