Semantic Scholar uses AI to extract papers important to this topic.
Summary. Background: The dodecapeptide HHLGGAKQAGDV (H12), corresponding to the fibrinogen γ‐chain carboxy‐terminal sequence… Expand Extracellular ATP, released upon tissue damage to the CNS, can evoke reactive astrogliosis. The released ATP activates P2… Expand We recently identified a novel hypothalamic neuropeptide inhibiting gonadotropin release in quail and termed it gonadotropin… Expand Crystals of human alpha-thrombin complexed with hirugen and the alpha-keto acid thrombin inhibitor APPA (p-amidinophenylpyruvate… Expand The X‐ray crystal structure of prethrombin2 (pre2), the immediate inactive precursor of α‐thrombin, has been determined at 2.0… Expand The X-ray crystallographic structure of the human alpha-thrombin complex with hirulog 3 (a potent, noncleavable hirudin-based… Expand Hirugen, a synthetic dodecapeptide corresponding to the carboxyl-terminal amino acids 53-64 of hirudin, binds within a deep… Expand The isomorphous structures of the hirugen (N-acetylhirudin 53'-64' with sulfato-Tyr63') and hirulog 1 (D-Phe-Pro-Arg-Pro-(Gly)4… Expand Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… Expand Hirudin, a potent 65-residue polypeptide inhibitor of alpha-thrombin found in the saliva of the leech Hirudo medicinalis, and… Expand