Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

hirugen

Known as: hirudin (53-64), O-sulfotyrosine(63)-, hirudin dodecapeptide, 63-O-sulfo-Tyr-hirudin (53-64) 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
In vertebrates (including teleosts), the pivotal hierarchical factor in the control of gonadotropin secretion is the hypothalamic… Expand
Is this relevant?
2009
2009
Summary.  Background: The dodecapeptide HHLGGAKQAGDV (H12), corresponding to the fibrinogen γ‐chain carboxy‐terminal sequence… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Extracellular ATP, released upon tissue damage to the CNS, can evoke reactive astrogliosis. The released ATP activates P2… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We recently identified a novel hypothalamic neuropeptide inhibiting gonadotropin release in quail and termed it gonadotropin… Expand
  • figure 1
  • figure 4
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
1995
1995
Crystals of human alpha-thrombin complexed with hirugen and the alpha-keto acid thrombin inhibitor APPA (p-amidinophenylpyruvate… Expand
Is this relevant?
Highly Cited
1994
Highly Cited
1994
The X‐ray crystal structure of prethrombin2 (pre2), the immediate inactive precursor of α‐thrombin, has been determined at 2.0… Expand
Is this relevant?
1991
1991
Hirugen, a synthetic dodecapeptide corresponding to the carboxyl-terminal amino acids 53-64 of hirudin, binds within a deep… Expand
Is this relevant?
1991
1991
The isomorphous structures of the hirugen (N-acetylhirudin 53'-64' with sulfato-Tyr63') and hirulog 1 (D-Phe-Pro-Arg-Pro-(Gly)4… Expand
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… Expand
  • figure 1
  • figure 3
  • figure 2
  • table I
  • figure 4
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Hirudin, a potent 65-residue polypeptide inhibitor of alpha-thrombin found in the saliva of the leech Hirudo medicinalis, and… Expand
Is this relevant?