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Hirudins

Known as: HIRUDIN, Hirudins [Chemical/Ingredient] 
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus… 
National Institutes of Health

Related topics

Related topics

32 relations

Broader (3)

AnticoagulantsAntithrombinsFibrinolytic Agents

Narrower (19)

CX 397HirudinM23 urokinaseSAK-RGD-K2-Hirul
Hirudin TherapyIn BloodLeechesProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Blood-compatible biomaterials by surface coating with a novel antithrombin-heparin covalent complex.
Review
2001
Review
2001
Pharmacologic preservation of the hemostatic system during cardiac surgery.
Highly Cited
2000
Highly Cited
2000
The effects of thrombin preconditioning on focal cerebral ischemia in rats
Review
1999
Review
1999
Anticoagulation Monitoring during Cardiac Surgery
Anticoagulation Monitoring during Cardiac Surgery: A Review of Current and Emerging Techniques George Despotis;Glenn Gravlee… 
Highly Cited
1993
Highly Cited
1993
Activation of fibrinolysis in the pericardial cavity during cardiopulmonary bypass
Highly Cited
1991
Highly Cited
1991
A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells.
Highly Cited
1990
Highly Cited
1990
Interactions of human mast cell tryptase with biological protease inhibitors.
Highly Cited
1990
Highly Cited
1990
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.
Highly Cited
1982
Highly Cited
1982
Pharmacological Studies on the Antithrombotic Action of Hirudin in Experimental Animals
Summary The pharmacodynamics and pharmacokinetics of hirudin were studied in dogs, rabbits and rats. Hirudin proved to be a well… 
Highly Cited
1981
Highly Cited
1981
Protease mitogenic response of chick embryo fibroblasts and receptor binding/processing of human alpha-thrombin.
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