Hirudins

Known as: HIRUDIN, Hirudins [Chemical/Ingredient] 
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
This article describes the pharmacology of approved parenteral anticoagulants. These include the indirect anticoagulants… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND The TIMI 9 trial evaluated whether the direct antithrombin hirudin is more effective than an indirect-acting… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The likelihood of restenosis is a major limitation of coronary angioplasty. We studied whether hirudin, a highly… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND The Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial compared the efficacy and safety of… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Adjunctive therapy for thrombolysis in acute myocardial infarction consists of platelet inhibition with aspirin and… (More)
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Highly Cited
1990
Highly Cited
1990
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin… (More)
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Highly Cited
1990
Highly Cited
1990
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… (More)
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Highly Cited
1989
Highly Cited
1989
The effect of recombinant hirudin and the dosage of heparin on acute platelet-thrombus deposition during carotid angioplasty in… (More)
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Highly Cited
1986
Highly Cited
1986
The dissociation constant for hirudin was determined by varying the concentration of hirudin in the presence of a fixed… (More)
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