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Hirudins
Known as:
HIRUDIN
, Hirudins [Chemical/Ingredient]
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus…
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National Institutes of Health
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Related topics
Related topics
32 relations
Broader (3)
Anticoagulants
Antithrombins
Fibrinolytic Agents
Narrower (19)
CX 397
Hirudin
M23 urokinase
SAK-RGD-K2-Hirul
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Hirudin Therapy
In Blood
Leeches
Process of secretion
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture
E. Anitua
,
Isabel Andí
,
+5 authors
A. Nurden
Journal of Orthopaedic Research
2005
Corpus ID: 5803950
Review
2000
Review
2000
Heparin-induced thrombocytopenia.
F. Fabris
,
G. Luzzatto
,
P. Stefani
,
B. Girolami
,
G. Cella
,
A. Girolami
Haematologica
2000
Corpus ID: 59730
BACKGROUND AND OBJECTIVE There are two types of heparin-induced thrombocytopenia (HIT). HIT I is characterized by a transitory…
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Review
2000
Review
2000
Snake venom proteases affecting hemostasis and thrombosis.
T. Matsui
,
Y. Fujimura
,
K. Titani
Biochimica et Biophysica Acta
2000
Corpus ID: 25700026
Highly Cited
1996
Highly Cited
1996
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes.
M. Simoons
New England Journal of Medicine
1996
Corpus ID: 2815702
BACKGROUND Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a…
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Highly Cited
1996
Highly Cited
1996
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial.
E. Antman
Circulation
1996
Corpus ID: 23271497
BACKGROUND The TIMI 9 trial evaluated whether the direct antithrombin hirudin is more effective than an indirect-acting…
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Highly Cited
1995
Highly Cited
1995
Cardiovascular Disease
L. Gallo
GWUMC Department of Biochemistry Annual Spring…
1995
Corpus ID: 546674
Shaker A. Mousa and Thomas M. Reilly The DuPont Merck Pharmaceutical Company Cardiovascular Diseases Div., Exp. Station…
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Review
1992
Review
1992
Natural protein proteinase inhibitors and their interaction with proteinases.
W. Bode
,
R. Huber
European Journal of Biochemistry
1992
Corpus ID: 23457391
The substrate-like 'canonical' inhibition by the 'small' serine proteinase inhibitors and the product-like inhibition by the…
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Highly Cited
1990
Highly Cited
1990
The structure of a complex of recombinant hirudin and human alpha-thrombin.
T. Rydel
,
K. Ravichandran
,
+4 authors
J. Fenton
Science
1990
Corpus ID: 22691646
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin…
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Highly Cited
1990
Highly Cited
1990
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
J. Weitz
,
M. Hudoba
,
D. Massel
,
J. Maraganore
,
J. Hirsh
Journal of Clinical Investigation
1990
Corpus ID: 25629109
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To…
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Highly Cited
1986
Highly Cited
1986
Kinetics of the inhibition of thrombin by hirudin.
S. Stone
,
J. Hofsteenge
Biochemistry
1986
Corpus ID: 23993374
The dissociation constant for hirudin was determined by varying the concentration of hirudin in the presence of a fixed…
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