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Hirudins
Known as:
HIRUDIN
, Hirudins [Chemical/Ingredient]
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus…
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National Institutes of Health
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Related topics
Related topics
32 relations
Broader (3)
Anticoagulants
Antithrombins
Fibrinolytic Agents
Narrower (19)
CX 397
Hirudin
M23 urokinase
SAK-RGD-K2-Hirul
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Hirudin Therapy
In Blood
Leeches
Process of secretion
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.
Karl‐Heinz Liesenfeld
,
H. Schäfer
,
I. Trocóniz
,
C. Tillmann
,
B. Eriksson
,
J. Stangier
British Journal of Clinical Pharmacology
2006
Corpus ID: 7517729
AIMS To describe the pharmacokinetic-pharmacodynamic (PK-PD) characteristics of the direct thrombin inhibitor dabigatran in hip…
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Review
2001
Review
2001
Pharmacologic preservation of the hemostatic system during cardiac surgery.
J. Levy
Annals of Thoracic Surgery
2001
Corpus ID: 24863195
Highly Cited
2000
Highly Cited
2000
Effects of various anticoagulant treatments on von Willebrand factor release in unstable angina.
G. Montalescot
,
J. Collet
,
+7 authors
Daniel Thomas
Journal of the American College of Cardiology
2000
Corpus ID: 36944758
Highly Cited
1994
Highly Cited
1994
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha.
L. Marco
,
M. Mazzucato
,
A. Masotti
,
Z. Ruggeri
Journal of Biological Chemistry
1994
Corpus ID: 9407293
Highly Cited
1994
Highly Cited
1994
Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial.
E. Topol
,
V. Fuster
,
+7 authors
M. Tannenbaum
Circulation
1994
Corpus ID: 46423216
BACKGROUND Coronary artery thrombosis plays an important pathophysiological role in unstable angina and non-Q-wave myocardial…
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Highly Cited
1993
Highly Cited
1993
Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets.
Takanobu Taniguchi
,
H. Kitagawa
,
+7 authors
H. Yamamura
Journal of Biological Chemistry
1993
Corpus ID: 26033893
Highly Cited
1993
Highly Cited
1993
Activation of fibrinolysis in the pericardial cavity during cardiopulmonary bypass
N. Tabuchi
,
J. Dehaan
,
P. Boonstra
,
W. Vanoeveren
1993
Corpus ID: 216037802
Highly Cited
1991
Highly Cited
1991
A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells.
J. Ngaiza
,
E. Jaffe
Biochemical and Biophysical Research…
1991
Corpus ID: 6752479
Highly Cited
1990
Highly Cited
1990
Interactions of human mast cell tryptase with biological protease inhibitors.
S. Alter
,
J. Kramps
,
A. Janoff
,
L. Schwartz
Archives of Biochemistry and Biophysics
1990
Corpus ID: 22340599
Highly Cited
1983
Highly Cited
1983
Monocyte chemotaxis: stimulation by specific exosite region in thrombin.
R. Bar-Shavit
,
A. Kahn
,
G. Wilner
,
J. Fenton
Science
1983
Corpus ID: 35284000
Human alpha-thrombin is a potent chemoattractant for human monocytes, with optimum activity occurring at about 10 nanomoles per…
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