Hirudins

Known as: HIRUDIN, Hirudins [Chemical/Ingredient] 
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus… (More)
National Institutes of Health

Related topics

Related topics

30 relations

Broader (3)

AnticoagulantsAntithrombinsFibrinolytic Agents

Narrower (17)

CX 397HirudinM23 urokinaseSAK-RGD-K2-Hirul
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Hirudin TherapyIn BloodLeechesProcess of secretion
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Papers overview

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Review
2012
Review
2012
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
This article describes the pharmacology of approved parenteral anticoagulants. These include the indirect anticoagulants… (More)
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Highly Cited
1999
Highly Cited
1999
Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study.
BACKGROUND The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia… (More)
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Highly Cited
1996
Highly Cited
1996
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial.
BACKGROUND The TIMI 9 trial evaluated whether the direct antithrombin hirudin is more effective than an indirect-acting… (More)
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Highly Cited
1995
Highly Cited
1995
A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. Helvetica Investigators.
BACKGROUND The likelihood of restenosis is a major limitation of coronary angioplasty. We studied whether hirudin, a highly… (More)
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Highly Cited
1994
Highly Cited
1994
Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial.
BACKGROUND The Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial compared the efficacy and safety of… (More)
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Highly Cited
1994
Highly Cited
1994
Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte…
BACKGROUND Adjunctive therapy for thrombolysis in acute myocardial infarction consists of platelet inhibition with aspirin and… (More)
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Highly Cited
1990
Highly Cited
1990
The structure of a complex of recombinant hirudin and human alpha-thrombin.
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin… (More)
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Highly Cited
1990
Highly Cited
1990
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… (More)
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Highly Cited
1989
Highly Cited
1989
Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor.
The effect of recombinant hirudin and the dosage of heparin on acute platelet-thrombus deposition during carotid angioplasty in… (More)
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Highly Cited
1986
Highly Cited
1986
Kinetics of the inhibition of thrombin by hirudin.
The dissociation constant for hirudin was determined by varying the concentration of hirudin in the presence of a fixed… (More)
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