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Hirudins

Known as: HIRUDIN, Hirudins [Chemical/Ingredient] 
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus… 
National Institutes of Health

Related topics

Related topics

32 relations

Broader (3)

AnticoagulantsAntithrombinsFibrinolytic Agents

Narrower (19)

CX 397HirudinM23 urokinaseSAK-RGD-K2-Hirul
Hirudin TherapyIn BloodLeechesProcess of secretion

Papers overview

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2001
2001
Anti-R-Hirudin Antibodies Reveal Clinical Relevance through Direct Functional Inactivation of R-Hirudin or Prolongation of R-Hirudin’s Plasma Halflife
Anti-R-Hirudin Antibodies Reveal Clinical Relevance through Direct Functional Inactivation of R-Hirudin or Prolongation of R… 
1998
1998
HBW 023 (recombinant hirudin) for the acceleration of thrombolysis and prevention of coronary reocclusion in acute myocardial infarction: results of a dose‐finding study (HIT‐II) by the…
ObjectiveTo define an optimal dose of hirudin that would improve early coronary artery Thrombolysis in Myocardial Infarction… 
1995
1995
Flow Cytometric Evaluation of Platelet Activation by Ionic or Nonionic Contrast Media and Modulation by Heparin and Recombinant Hirudin
RATIONALE AND OBJECTIVES.The purpose of this study was to investigate the platelet activation properties of ionic and nonionic… 
Review
1991
Review
1991
Structure-Activity Relationships of Recombinant Hirudins
The complex formation between thrombin and hirudin is unique among other serine proteinase-inhibitor complexes. The serpines… 
Review
1989
Review
1989
Comparison of Hirudins
Natural hirudin as a crude extract of the salivary glands of the leech, Hirudo medicinalis L.,was first prepared and discovered… 
1987
1987
Proton Nuclear Magnetic Resonance Study of Hirudin: Resonance Assignment and Secondary Structure?
The /sup 1/H NMR spectrum of the 65-residue protein hirudin is assigned in a sequential manner by using a combination of two… 
Highly Cited
1979
Highly Cited
1979
Dissociation of thrombin from platelets by hirudin. Evidence for receptor processing.
Hirudin inhibited the binding of human 125I-alpha-thrombin to the saturable, but not the nonsaturable, sites on washed human… 
1976
1976
Characteristics of the association between prothrombin fragment 2 and alpha-thrombin.
The esterolytic activity of bovine alpha-thrombin on the synthetic substrate N-alpha-p-tosyl-L-arninine methyl ester (TosArgOMe… 
1976
1976
Evidence that functional subunits of antihemophilic factor (Factor VIII) are linked by noncovalent bonds.
Partially purified human antihemophilic factor (AHF, factor VIII), when treated with high concentrations of salt, has been shown… 
1969
1969
The role of heparin in intrinsic blood coagulation.
A number of inhibitors of intrinsic blood coagulation have been examined. Particular emphasis was placed on heparin, heparin…