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Hirudins

Known as: HIRUDIN, Hirudins [Chemical/Ingredient] 
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus… 
National Institutes of Health

Related topics

Related topics

32 relations

Broader (3)

AnticoagulantsAntithrombinsFibrinolytic Agents

Narrower (19)

CX 397HirudinM23 urokinaseSAK-RGD-K2-Hirul
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Hirudin TherapyIn BloodLeechesProcess of secretion
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
Heparin-induced thrombocytopenia.
BACKGROUND AND OBJECTIVE There are two types of heparin-induced thrombocytopenia (HIT). HIT I is characterized by a transitory… 
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Highly Cited
1996
Highly Cited
1996
A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes.
  • M. Simoons
  • The New England journal of medicine
  • 1996
  • Corpus ID: 2815702
BACKGROUND Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a… 
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Highly Cited
1996
Highly Cited
1996
Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial.
BACKGROUND The TIMI 9 trial evaluated whether the direct antithrombin hirudin is more effective than an indirect-acting… 
Highly Cited
1995
Highly Cited
1995
Cardiovascular Disease
  • L. Gallo
  • GWUMC Department of Biochemistry Annual Spring…
  • 1995
  • Corpus ID: 546674
Shaker A. Mousa and Thomas M. Reilly The DuPont Merck Pharmaceutical Company Cardiovascular Diseases Div., Exp. Station… 
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Review
1992
Review
1992
Natural protein proteinase inhibitors and their interaction with proteinases.
The substrate-like 'canonical' inhibition by the 'small' serine proteinase inhibitors and the product-like inhibition by the… 
Highly Cited
1991
Highly Cited
1991
Refined structure of the hirudin-thrombin complex.
The structure of a recombinant hirudin (variant 2, Lys47) human alpha-thrombin complex has been refined using restrained least… 
Highly Cited
1990
Highly Cited
1990
The structure of a complex of recombinant hirudin and human alpha-thrombin.
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin… 
Highly Cited
1990
Highly Cited
1990
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To… 
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Highly Cited
1990
Highly Cited
1990
Crystal structure of the thrombin‐hirudin complex: a novel mode of serine protease inhibition.
Thrombin is a serine protease that plays a central role in blood coagulation. It is inhibited by hirudin, a polypeptide of 65… 
Highly Cited
1986
Highly Cited
1986
Kinetics of the inhibition of thrombin by hirudin.
The dissociation constant for hirudin was determined by varying the concentration of hirudin in the presence of a fixed… 
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