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CX 397

Known as: CX-397 
National Institutes of Health

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2 relations

Broader (2)

HirudinsRecombinant Proteins

Papers overview

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Review
2006
Review
2006
CX‐397: A Novel Antithrombotic Recombinant Hirudin Analog
Cardiovascular Drug Reviews Vol. 18, No. 1, pp. 47–60 © 2000 Neva Press, Branford, Connecticut CX-397 is a recombinant hirudin… 
Review
2003
Review
2003
Finding of an isoleucine derivative of a recombinant protein for pharmaceutical use.
1999
1999
Pharmacological Effects of a Novel Recombinant Hirudin, CX-397, In Vivo and In Vitro: Comparison with Recombinant Hirudin Variant-1, Heparin, and Argatroban
Summary The novel recombinant hirudin analog CX-397 was investigated with respect to its pharmacological activity and… 
1998
1998
Anti-thrombotic Effects of CX-397, a Recombinant Hirudin Analog, in a Canine Model of Coronary Artery Thrombosis
Summary CX-397, a recombinant hirudin analog, is a potent and specific inhibitor of human α-thrombin. We conducted a comparative… 
1997
1997
Reevaluating the effects of tyrosine iodination of recombinant hirudin on its thrombin inhibition kinetics.
1996
1996
First phase test of selective antithrombin medicine CX-397 in normal adult man. Single time and daily continuous intravenous instillation test.
1995
1995
Antithrombotic effect of a novel recombinant hirudin analogue, CX‐397, in a rat arterial thrombosis model
1 The antithrombotic effect of a new specific thrombin inhibitor, CX‐397, was examined in a photochemically‐induced arterial… 
1993
1993
CX-397, a novel recombinant hirudin analog having a hybrid sequence of hirudin variants-1 and -3.
To elucidate the differential roles of N- and C-terminal halves of hirudins in thrombin inhibition, we produced novel recombinant… 
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