himbacine

Known as: 4-((E)-2-(1,6-Dimethyl-2-piperidinyl)ethenyl)-3-methyldecahydronaphtho(2,3-c)furan-1(3H)-one 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2016
051019862016

Papers overview

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Highly Cited
2008
Highly Cited
2008
The discovery of an exceptionally potent series of thrombin receptor (PAR-1) antagonists based on the natural product himbacine… (More)
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2006
2006
Airway remodeling is a structural alteration associated with chronic inflammatory and obstructive airway diseases, wherein… (More)
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2001
2001
The success of the M(1)-selective muscarinic antagonist pirenzepine in preventing myopia development in animal models implicates… (More)
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1999
1999
A parallel synthesis of racemic himbacine analogs was carried out by N-alkylation of various commercially available cyclic amine… (More)
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1999
1999
Himbacine (1), a complex piperidine alkaloid isolated from the bark of Australian magnolias, is a promising lead in Alzheimer's… (More)
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1992
1992
The binding potencies for the putative M2-selective antagonist himbacine were determined in radioligand binding and in functional… (More)
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Highly Cited
1991
Highly Cited
1991
A variety of muscarinic antagonists are currently used as tools to pharmacologically subclassify muscarinic receptors into M1, M2… (More)
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1990
1990
We have carried out an extensive pharmacological characterization of muscarinic binding sites in rabbit lung and chicken heart in… (More)
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1988
1988
1. The action of methoctramine and himbacine at muscarinic receptors has been studied using guinea-pig isolated trachea… (More)
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1986
1986
The antimuscarinic actions of himbacine were compared with those of atropine and/or homatropine on atria, ileum and trachea from… (More)
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