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Gradient-Tailored Water Suppression for 1H-15N HSQC Experiments Optimized to Retain Full Sensitivity
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Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor.
TLDR
The results suggest that the allosteric site for gallamine binding in the m2 receptor residues at or near the putative third outer domain and that both the EDGE motif and Asp-97 play an essential role in the interaction between the two sites.
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Membrane-associated reactions in ubiquinone biosynthesis in Escherichia coli. 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase.
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Characterization of five genes in the upper-pathway operon of TOL plasmid pWW0 from Pseudomonas putida and identification of the gene products
TLDR
The upper operon of the TOL plasmid pWW0 of Pseudomonas putida encodes a set of enzymes which transform toluene and xylenes to benzoate and toluates and synthesizes a 52-kilodalton polypeptide of unknown function.
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Biochemical and Genetic Studies on Ubiquinone Biosynthesis in Escherichia coli K-12: 4-Hydroxybenzoate Octaprenyltransferase
TLDR
The results of genetic analysis suggest that each of the ubiquinone-deficient mutants of Escherichia coli carries a mutation in a gene designated ubiA which can be represented at minute 79 on the E. coli chromosome map, which suggested that the ubiB gene is the structural gene coding for this enzyme.
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Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.
It has been demonstrated previously that amilorides can interact with a well defined allosteric site on the human alpha(2A)-adrenergic receptor. In this study, the question was explored as to whether…
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Deoxycholic acid degradation by a pseudomonas sp: Phenolic and neutral products
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Gene order of the TOL catabolic plasmid upper pathway operon and oxidation of both toluene and benzyl alcohol by the xylA product
TLDR
Determination of upper pathway enzyme levels in bacteria carrying Tn5 insertion mutant derivatives of plasmid pWW0-161 has shown that the genes for upper pathway enzymes are organized in an operon with the following order: promoter-xylC (benzaldehyde dehydrogenase gene[s],xylA (xylene oxygenase gene)[s], andxylB (benZyl alcohol dehydrogen enzyme gene).
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Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.
TLDR
Both the binding and functional data provide further support for the existence of a well defined allosteric site on the human alpha(2A)-adrenergic receptor.
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Analysis and Manipulation of Plasmid-Encoded Pathways for the Catabolism of Aromatic Compounds by Soil Bacteria
TLDR
Soil and water bacteria in general and members of the genus Pseudomonas in particular are able to evolve rapidly new metabolic activities in response to changes in environmental conditions, and many catabolic pathways are specified by plasmids, elements known to be instrumental for rapid genetic change in bacteria.
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