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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Assessment of Alzheimer’s disease (AD)-related neurofibrillary pathology requires a procedure that permits a sufficient differentiation between initial, intermediate, and late stages. The gradualExpand
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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
One year ago, in this journal, we published a recommended nomenclature for the neuropathologic subtypes of frontotemporal lobar degeneration (FTLD) [7]. A major impetus behind this was to resolve theExpand
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Primary age-related tauopathy (PART): a common pathology associated with human aging
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains withExpand
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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Abstract Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potentialExpand
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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP).Expand
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The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in mitochondria.Expand
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Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.
BACKGROUND There is a clear need to develop an objective diagnostic test for Alzheimer disease (AD). Changes in the levels of cerebrospinal fluid (CSF) tau protein and beta-amyloid 42 (Abeta42)Expand
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Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration : consensus recommendations
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Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
We examined the immunoreactivity of ubiquitin-binding protein p62 and its association with ubiquitin (Ub), α-synuclein, and paired helical filament (PHF)-tau in the affected brain areas of humanExpand
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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
TLDR
This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. Expand
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