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heptelidic acid

Known as: Spiro(2-benzoxepin-9(3H),2'-oxirane)-4-carboxylic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methylethyl)-1-oxo-, koningic acid 
National Institutes of Health

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Sesquiterpenes

Papers overview

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1998
1998
A transient brain ischemia- and bacterial endotoxin-induced glial iNOS expression and NO-induced neuronal apoptosis.
Highly Cited
1997
Highly Cited
1997
Koningic Acid (a Potent Glyceraldehyde‐3‐Phosphate Dehydrogenase Inhibitor)‐Induced Fragmentation and Condensation of DNA in NG108‐15 Cells
Abstract: We examined nitric oxide (NO)‐induced cell death in NG108‐15 cells using NO donors. Both sodium nitroprusside (SNP) and… 
1994
1994
Inhibition of glyceraldehyde-3-phosphate dehydrogenase by phosphorylated epoxides and alpha-enones.
Pentalenolactone and koningic acid are antibiotics known for their potent inhibition of the glycolytic enzyme glyceraldehyde-3… 
1994
1994
Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone. 2. Identification of the site of alkylation by tetrahydropentalenolactone.
Incubation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with the antibiotic pentalenolactone (3) results in… 
1993
1993
A glyceraldehyde-3-phosphate dehydrogenase with eubacterial features in the amitochondriate eukaryote, Trichomonas vaginalis
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), localized in the cytosol of Trichomonas vaginalis, was partially purified. The… 
1993
1993
Cloning of two isozymes of Trichoderma koningii glyceraldehyde-3-phosphate dehydrogenase with different sensitivity to koningic acid.
1992
1992
Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources.
1991
1991
Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.
1990
1990
Two glyceraldehyde-3-phosphate dehydrogenase isozymes from the koningic acid (heptelidic acid) producer Trichoderma koningii.
The sesquiterpene lactone koningic acid (heptelidic acid) irreversibly inactivated glyceraldehyde-3-phosphate dehydrogenase [D… 
1988
1988
Inactivation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by koningic acid.
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