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hepsulfam

Known as: sulfamic acid 1,7-heptanediyl ester, Sulfamic acid, 1,7-heptanediyl ester, 1,7-Heptanediyl Ester Sulfamic Acid 
A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam… 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

NSC 329680

Broader (1)

Sulfonic Acids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia
SummarySince 1978, over 50 clinically useful antitumor drugs or new candidate antitumor agents have been evaluated in vivo… 
2000
2000
Evaluation of dimethylaminosulfonates of alkane diols as a novel group of anticancer agents.
1995
1995
Molecular pharmacology of hepsulfam, NSC 3296801: identification of alkylated nucleosides, alkylation site, and site of DNA cross-linking.
We have determined that hepsulfam, in common with its structural homologue busulfan, alkylates both free guanosine and GMP in DNA… 
1993
1993
In vitro cytotoxicity of hepsulfam against human tumor cell lines and primary human tumor colony forming units
Hepsulfam (sulfamic acid 1,7‐heptanediyl ester, NSC 329680) is an alkylating agent currently in Phase I clinical trials… 
1992
1992
Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.
Hepsulfam (NSC 329680, 1,7-heptanediol disulfamate) is an alkylating agent that showed excellent activity against mouse and human… 
1992
1992
Preclinical activity off hepsulfam and busulfan in solid human tumor xenografts and human bone marrow
Hepsulfam (1,7-heptanediol disulfamate, NSC 329680) is a new antlneoplastic alkanesulfonate agent which has demonstrated a… 
1991
1991
A phase I clinical and pharmacokinetic trial of hepsulfam.
Hepsulfam (1,7-heptanediol-bis-sulfamate) is one of a series of bis-sulfamate acid esters that was synthesized in an attempt to… 
1991
1991
Phase I and pharmacokinetic study of hepsulfam (NSC 329680).
Hepsulfam (NSC 329680), a bifunctional alkylating agent structurally related to busulfan, has entered clinical trial based on its… 
1990
1990
Mechanisms of toxicity of hepsulfam in human tumor cell lines.
1,7-Heptanediol disulfamate (hepsulfam, NSC 329680) is a new anti-cancer agent which is currently undergoing phase I clinical… 
1990
1990
In vitro studies on the mechanism of action of hepsulfam in chronic myelogenous leukemia patients.
In the present study we have characterized the cytotoxicity and DNA damage induced by hepsulfam and busulfan in cells isolated… 
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