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HIV-1 Protease Inhibitor Induced Oxidative Stress Suppresses Glucose Stimulated Insulin Release: Protection with Thymoquinone
TLDR
The present findings imply a direct role of ROS in PI induced deleterious effects on pancreatic β-cells and suggest that TQ may be used as a potential therapeutic agent to normalize the dysregulated insulin production observed in HAART treated patients. Expand
Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent
TLDR
The data suggest that SDF-1alpha-induced expression of CXCR4 in PC-3 cells is dependent on MEK/ERK signaling cascade and NF-kappaB activation. Expand
Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation.
TLDR
The results suggest that T-type Ca2+ channel antagonism/silencing may reduce cellular proliferation in mitogenic breast cells. Expand
Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response.
TLDR
Analysis of mechanisms associated with overexpression of metallothionein using inducers that increased MT transcripts and stimulated growth in MCF-7 cells suggests a potential role for NFkappaB in mediating the antiapoptotic effects of MT. Expand
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species
TLDR
Analysis of mechanism of action of TQ in androgen receptor (AR)-independent and AR naïve prostate cancer cells, as models of aggressive prostate cancers, suggests that TQ-induced cell death is primarily due to increased ROS generation and decreased GSH levels, and is independent of AR activity. Expand
Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus
TLDR
The present study in six patients without symptoms who were infected with human immunodeficiency virus was undertaken to determine if coadministration of valproic acid which, like zidovudine, is metabolized by glucuronidation, would alter zidvudine disposition. Expand
Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer
TLDR
Cytoplasmic SOX9 can serve as a valuable prognostic marker for IDCs and metastatic breast cancer and its significant correlation with breast tumor cell proliferation implies thatSOX9 directly contributes to the poor clinical outcomes associated with invasive breast cancer. Expand
HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells
TLDR
It is indicated that chronic HAART exposure increases oxidative stress in endothelial cells and induces mononuclear cell recruitment, which may eventually precipitate the cardiovascular disease observed in HIV-1+ individuals on antiretroviral therapy. Expand
Suppression of clonogenic potential of human bone marrow mesenchymal stem cells by HIV type 1: putative role of HIV type 1 tat protein and inflammatory cytokines.
TLDR
It is suggested that HIV-1 infection of stromal cells may produce inhibitory factors that suppress the clonogenic potential of MSCs. Expand
The pharmacological effects of allicin, a constituent of garlic oil
TLDR
It is reported that allicin inhibits human platelet aggregationin vitro without affecting cyclooxygenase or thromboxane synthase activity or cyclic adenosine monophosphate levels. Expand
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