Mechanisms of toxicity of hepsulfam in human tumor cell lines.

@article{Pacheco1990MechanismsOT,
  title={Mechanisms of toxicity of hepsulfam in human tumor cell lines.},
  author={Diane Y. Pacheco and Claire Cook and Jonathan R Hincks and Neil W. Gibson},
  journal={Cancer research},
  year={1990},
  volume={50 23},
  pages={
          7555-8
        }
}
1,7-Heptanediol disulfamate (hepsulfam, NSC 329680) is a new anti-cancer agent which is currently undergoing phase I clinical trials. The mechanism of action of this compound is not clear at this time. We have recently shown that hepsulfam was more toxic to L1210 leukemia cells than was busulfan. Consistent with the difference in toxicity, we found that hepsulfam induced DNA interstrand cross-links in L1210 mouse leukemia cells, whereas busulfan did not. In the present study, we have found that… CONTINUE READING

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