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heme oxygenase (decyclizing) activity

Known as: haem oxygenase activity, heme oxidase activity, heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) 
Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. [EC:1.14.99.3]
National Institutes of Health

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Heme Oxygenase (Decyclizing)

Papers overview

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Highly Cited
2000
Highly Cited
2000
Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction.
Bilirubin is a potent antioxidant generated intracellularly during the degradation of heme by the enzyme heme oxygenase. The… 
Highly Cited
2000
Highly Cited
2000
Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress.
The inducible isoform of haem oxygenase (HO-1) has been proposed as an effective system to counteract oxidant-induced cell injury… 
Highly Cited
1994
Highly Cited
1994
Carbon monoxide as an endogenous modulator of hepatic vascular perfusion.
Carbon monoxide (CO) generated by heme oxygenase has recently been considered a neural messenger in brain. This observation… 
Highly Cited
1993
Highly Cited
1993
Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin.
Highly Cited
1990
Highly Cited
1990
Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.
Cytochrome P450 content and activities are increased in the kidneys of spontaneously hypertensive rats (SHR) as compared with… 
Highly Cited
1989
Highly Cited
1989
The human 32‐kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase
Highly Cited
1987
Highly Cited
1987
Transcriptional control of rat heme oxygenase by heat shock.
Highly Cited
1980
Highly Cited
1980
Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450.
Highly Cited
1976
Highly Cited
1976
Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity.
Highly Cited
1974
Highly Cited
1974
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity.
Treatment of rats in vivo with cobalt chloride stimulated heme oxidation by hepatic microsomes to levels up to 800% above… 
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