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Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.
It is demonstrated that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway, and using antibodies and specific inhibitors of the mitogen-activated protein kinase (MAPK) pathways, data is provided implicating p38 MAPK inCurcumin-mediated ho-1 induction.
The therapeutic potential of carbon monoxide
An overview of the physiology of CO is provided, the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation are summarized, and the development and therapeutic options for the exploitation of this simple gaseous molecule are discussed.
Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities
- R. Motterlini, James E. Clark, R. Foresti, P. Sarathchandra, B. Mann, C. Green
- Biology, ChemistryCirculation research
- 8 February 2002
It is reported that a series of transition metal carbonyls, termed here carbon monoxide-releasing molecules (CO-RMs), liberate CO to elicit direct biological activities and caused sustained vasodilation in precontracted rat aortic rings, attenuated coronary vasoconstriction in hearts ex vivo, and significantly reduced acute hypertension in vivo.
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress.
Cardioprotective Actions by a Water‐Soluble Carbon nMonoxide‐Releasing Molecule
It is found that tricarbonylchloro(glycinato)ruthenium(II) (CORM‐3) is stable in water at acidic pH but in physiological buffers rapidly liberates CO in solution, corroborate the notion that transition metal carbonyls could be used as carriers to deliver CO and highlight the bioactivity and potential therapeutic features of CO‐RMs in the mitigation of cardiac dysfunction.
Therapeutic applications of carbon monoxide-releasing molecules
A novel class of substances, CO-releasing molecules (CO-RMs), which are capable of exerting a variety of pharmacological activities via the liberation of controlled amounts of CO in biological systems are identified.
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
- R. Motterlini, Philip Sawle, C. Green
- BiologyFASEB journal : official publication of the…
- 1 February 2005
The results reveal that the bioactivities exerted by CORM‐A1 reflect its intrinsic biochemical behavior of a slow CO releaser, which may be advantageous in the treatment of chronic conditions that require CO to be delivered in a carefully controlled manner.
Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
- Philip Sawle, R. Foresti, B. Mann, T. Johnson, C. Green, R. Motterlini
- BiologyBritish journal of pharmacology
- 1 July 2005
Results indicate that CO liberated by CORM‐2 andCORM‐3 significantly suppresses the inflammatory response elicited by LPS in cultured macrophages and suggest that CO carriers can be used as an effective strategy to modulate inflammation.
Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers.
- G. Scapagnini, R. Foresti, V. Calabrese, A. G. Giuffrida Stella, C. Green, R. Motterlini
- BiologyMolecular pharmacology
- 1 March 2002
Results suggest that regulation of HO-1 expression by polyphenolic compounds is evoked by a distinctive mechanism which is not necessarily linked to changes in glutathione but might depend on redox signals sustained by specific and targeted sulfydryl groups.
The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis.
The current ideas on the role of CO-heme oxygenase and NO-nitric oxide synthase in cell signaling and how the two systems are interrelated are highlighted.