Heme Oxygenase (Decyclizing)
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The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress. The anti-inflammatory properties of… Expand The heme oxygenase (HO) system consists of two forms identified to date: the oxidative stress-inducible protein HO-1 (HSP32) and… Expand Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 126.96.36.199), which catabolizes heme to biliverdin, carbon… Expand Attack by reactive oxygen intermediates, common to many kinds of cell/tissue injury, has been implicated in the development of… Expand Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization… Expand Phagocyte-mediated oxidant damage to vascular endothelium is likely involved in various vasculopathies including atherosclerosis… Expand In biological systems oxidation of heme is carried out by two isozymes of the microsomal heme oxygenase, HO-1 and HO-2. HO-1 is… Expand Abstract This study characterizes microsomal heme oxygenase, a previously undescribed enzyme which catalyzes the oxidation of… Expand The phenomenon of growth, decline and death—aging—has been the source of considerable speculation (1, 8, 10). This cycle seems to… Expand