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hematopoietic stem cell differentiation

Known as: haematopoietic stem cell differentiation, haemopoietic stem cell differentiation, hemopoietic stem cell differentiation 
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains… (More)

Topic mentions per year

Topic mentions per year

1971-2017
051019712017

Related topics

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3 relations

Broader (1)

Hematopoiesis
positive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
hematopoietic stem cell differentiation
Hematopoiesis
regulation of hematopoietic stem cell differentiation
positive regulation of hematopoietic stem cell differentiation

Papers overview

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Highly Cited
2013
Highly Cited
2013
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation… (More)
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Highly Cited
2013
Highly Cited
2013
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire.
Stem cell differentiation pathways are most often studied at the population level, whereas critical decisions are executed at the… (More)
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Highly Cited
2011
Highly Cited
2011
Dnmt3a is essential for hematopoietic stem cell differentiation
Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells obstructs differentiation; however, the role… (More)
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2011
2011
PKCδ-induced PU.1 phosphorylation promotes hematopoietic stem cell differentiation to dendritic cells.
Human CD34(+) hematopoietic stem cells (HSCs) exhibit the potential to differentiate into a variety of specialized blood cells… (More)
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2010
2010
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and cell-extrinsic cues. In addition to… (More)
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Highly Cited
2007
Highly Cited
2007
Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis.
Hematopoietic stem cells (HSC) produce all blood cell lineages by virtue of their capacity to self-renew and differentiate into… (More)
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Highly Cited
2003
Highly Cited
2003
DNA helicase Srs2 disrupts the Rad51 presynaptic filament.
Mutations in the Saccharomyces cerevisiae gene SRS2 result in the yeast's sensitivity to genotoxic agents, failure to recover or… (More)
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Highly Cited
2001
Highly Cited
2001
Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells.
Clonogenic multipotent mouse hematopoietic stem cells (HSCs) and progenitor cells are contained within the c-kit(+) (K) lineage… (More)
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Highly Cited
2001
Highly Cited
2001
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Increasing use of purified or cultured human hematopoietic cells as transplants has revealed an urgent need for better methods to… (More)
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Highly Cited
1983
Highly Cited
1983
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.
Multipotential hematopoietic progenitor cell lines have been established from nonadherent cell populations removed from… (More)
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