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Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region
The adult hematopoietic system of mammals is a dynamic hierarchy of cells with the hematopoietic stem cell at its foundation. During embryonic development, the source and expansion potential of thisExpand
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Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter
Haematopoietic stem cells (HSCs) are the founder cells of the adult haematopoietic system, and thus knowledge of the molecular program directing their generation during development is important forExpand
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Development of hematopoietic stem cell activity in the mouse embryo.
The precise time of appearance of the first hematopoietic stem cell activity in the developing mouse embryo is unknown. Recently the aorta-gonad-mesonephros region of the developing mouse embryo hasExpand
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The murine placenta contains hematopoietic stem cells within the vascular labyrinth region.
In the midgestation murine embryo, several major vascular tissues contain hematopoietic stem cell (HSC) activity. These include the aorta-gonad-mesonephros region (AGM), yolk sac, and fetal liver.Expand
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Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
Hematopoietic stem cells (HSCs) are first found in the aorta-gonad-mesonephros region and vitelline and umbilical arteries of the midgestation mouse embryo. Runx1 (AML1), the DNA binding subunit of aExpand
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GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells
GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the mouse leads toExpand
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Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo
The aorta–gonad–mesonephros (AGM) region is a potent hematopoietic site within the mammalian embryo body, and the first place from which hematopoietic stem cells (HSCs) emerge. Within the complexExpand
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Of lineage and legacy: the development of mammalian hematopoietic stem cells
The hematopoietic system is one of the first complex tissues to develop in the mammalian conceptus. Of particular interest in the field of developmental hematopoiesis is the origin of adult boneExpand
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An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.
Cytokines are important in adult hematopoiesis, yet their function in embryonic hematopoiesis has been largely unexplored. During development, hematopoietic stem cells (HSCs) are found in theExpand
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Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system. Despite their importance, hematopoietic clusters have not beenExpand
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