helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:mah, ISBN:0198506732]
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Helicases unwind duplex DNA ahead of the polymerases at the replication fork. However, the identity of the eukaryotic replicative… (More)
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Highly Cited
2008
Highly Cited
2008
Nonsense-mediated mRNA decay (NMD) eliminates mRNAs containing a premature translation termination codon through the recruitment… (More)
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Highly Cited
2005
Highly Cited
2005
Most mRNAs contain secondary structure, yet their codons must be in single-stranded form to be translated. Until now, no helicase… (More)
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Highly Cited
2004
Highly Cited
2004
RNA polymerase functions like a molecular motor that can convert chemical energy into the work of strand separation and… (More)
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Highly Cited
2001
Highly Cited
2001
The minichromosome maintenance (Mcm) proteins 2-7 are required for both the initiation and elongation steps of chromosomal DNA… (More)
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Highly Cited
1999
Highly Cited
1999
Mcm proteins play an essential role in eukaryotic DNA replication, but their biochemical functions are poorly understood… (More)
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Highly Cited
1998
Highly Cited
1998
Werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. The… (More)
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Highly Cited
1990
Highly Cited
1990
The mechanism of ribosome binding to eucaryotic mRNAs is not well understood, but it requires the participation of eucaryotic… (More)
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Highly Cited
1990
Highly Cited
1990
Genetic studies of adeno-associated virus (AAV) indicate that two AAV genes are required for viral DNA replication: the… (More)
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Highly Cited
1989
Highly Cited
1989
IT has been proposed that p68, a nuclear protein of relative molecular mass 68,000, functions in the regulation of cell growth… (More)
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