hedamycin

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2017
02419662017

Papers overview

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2009
2009
Hedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin… (More)
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2005
2005
Expression of the antiapoptotic protein survivin is associated with cancer cell viability and drug resistance. Thus, control of… (More)
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2005
2005
Genotoxic treatments, such as UV light, camptothecin, and adozelesin, stall DNA replication and subsequently generate DNA strand… (More)
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2004
2004
Long-term exposure (72 h) to hedamycin, a monofunctional DNA alkylator of the pluramycin class of antitumor antibiotics… (More)
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1998
1998
The DNA sequence specificity of hedamycin damage was compared using two techniques: Ligation-mediated PCR (LMPCR) and Linear… (More)
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1996
1996
2D NMR spectroscopic methods have been used to determine the structure of the adduct formed between the antitumor antibiotic… (More)
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1995
1995
BACKGROUND The pluramycins are a class of antitumor antibiotics that exert their biological activity through interaction with DNA… (More)
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1995
1995
Covalent binding of the antitumour antibiotic hedamycin to the self-complementary hexadeoxyribonucleotide 5'-CACGTG-3' has been… (More)
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1994
1994
TBP (TATA box binding protein), a general transcription factor required for proper initiation of gene expression by RNA… (More)
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1982
1982
Hedamycin forms a stable complex with DNA and introduces alkali labile linkages in the DNA. These labile linkages are located at… (More)
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