hedamycin
National Institutes of Health
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Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in…
Genotoxic treatments, such as UV light, camptothecin, and adozelesin, stall DNA replication and subsequently generate DNA strand…
Long-term exposure (72 h) to hedamycin, a monofunctional DNA alkylator of the pluramycin class of antitumor antibiotics…
Hedamycin, a member of the pluramycin class of antitumour antibiotics, consists of a planar anthrapyrantrione chromophore to…
The DNA sequence specificity of hedamycin (HDM) damage was investigated in the single-copy human beta-globin gene cluster in an…
2D NMR spectroscopic methods have been used to determine the structure of the adduct formed between the antitumor antibiotic…
Hedamycin forms a stable complex with DNA and introduces alkali labile linkages in the DNA. These labile linkages are located at…
The binding of the antibiotic hedamycin to DNA was evaluated by density gradient centrifugation in CsCl to determine the type I…
Interpretation of the chemical and spectral (IR., UV., 1H- and 13C-NMR.) properties of the antitumor antibiotic hedamycin…