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hedamycin

 
National Institutes of Health

Papers overview

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2011
2011
Bacterial aromatic polyketides that include many antibiotic and antitumor therapeutics are biosynthesized by the type II… Expand
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2009
2009
Hedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin… Expand
Highly Cited
2005
Highly Cited
2005
  • J. Wu, X. Ling, +6 authors F. Li
  • Journal of Biological Chemistry
  • 2005
  • Corpus ID: 32164822
Expression of the antiapoptotic protein survivin is associated with cancer cell viability and drug resistance. Thus, control of… Expand
Highly Cited
2004
Highly Cited
2004
The biosynthetic gene cluster for the pluramycin-type antitumor antibiotic hedamycin has been cloned from Streptomyces… Expand
1995
1995
BACKGROUND The pluramycins are a class of antitumor antibiotics that exert their biological activity through interaction with DNA… Expand
1995
1995
The sequence selectivity of DNA alkylation by the recently isolated pluramycin antitumour antibiotic DC92-B has been investigated… Expand
Highly Cited
1994
Highly Cited
1994
TBP (TATA box binding protein), a general transcription factor required for proper initiation of gene expression by RNA… Expand
Highly Cited
1994
Highly Cited
1994
Intercalating, minor groove binding, and covalently bonding drugs were evaluated by mobility shift assays for their ability to… Expand
1982
1982
  • G. Bennett
  • Nucleic acids research
  • 1982
  • Corpus ID: 6093693
Hedamycin forms a stable complex with DNA and introduces alkali labile linkages in the DNA. These labile linkages are located at… Expand
1970
1970
Abstract 1. The interaction of hedamycin, an antibiotic from Streptomyces griseoruber with polynucleotides and the effect of this… Expand