Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

hedamycin

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Bacterial aromatic polyketides that include many antibiotic and antitumor therapeutics are biosynthesized by the type II… Expand
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 3
Is this relevant?
2009
2009
Hedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin… Expand
Is this relevant?
2007
2007
We have previously shown that hedamycin, a GC-rich DNA-binding antitumor agent, downregulates survivin transcription (Wu et al… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Expression of the antiapoptotic protein survivin is associated with cancer cell viability and drug resistance. Thus, control of… Expand
Is this relevant?
2005
2005
Genotoxic treatments, such as UV light, camptothecin, and adozelesin, stall DNA replication and subsequently generate DNA strand… Expand
Is this relevant?
2004
2004
The biosynthetic gene cluster for the pluramycin-type antitumor antibiotic hedamycin has been cloned from Streptomyces… Expand
Is this relevant?
2004
2004
Long-term exposure (72 h) to hedamycin, a monofunctional DNA alkylator of the pluramycin class of antitumor antibiotics… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1995
1995
BACKGROUND The pluramycins are a class of antitumor antibiotics that exert their biological activity through interaction with DNA… Expand
Is this relevant?
1994
1994
TBP (TATA box binding protein), a general transcription factor required for proper initiation of gene expression by RNA… Expand
Is this relevant?
1994
1994
Intercalating, minor groove binding, and covalently bonding drugs were evaluated by mobility shift assays for their ability to… Expand
Is this relevant?