Selective and Potent In Vitro Antimalarial Activities Found in Four Microbial Metabolites

@article{Ui2007SelectiveAP,
  title={Selective and Potent In Vitro Antimalarial Activities Found in Four Microbial Metabolites},
  author={Hideaki Ui and Aki Ishiyama and Hitomi Sekiguchi and Miyuki Namatame and Aki Nishihara and Yōko Takahashi and Kazuro Shiomi and Kazuhiko Otoguro and Satoshi O̅mura},
  journal={The Journal of Antibiotics},
  year={2007},
  volume={60},
  pages={220-222}
}
Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin α exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of… CONTINUE READING

Figures, Tables, and Topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).

  • FEMS microbiology letters
  • 2009
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 16 REFERENCES

Anti-Plasmodial activity of bisbenzylisoquinoline alkaloids from Michelia figo leaves

A Phrutivorapongkul, C Ichino, +6 authors S. Ōmura
  • Thai J. Health Res
  • 2006
VIEW 1 EXCERPT

Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5. Selective inhibiton by triacsin C and thiazoidinediones

Kim J-H, RA LewinTM.Coleman
  • J Biol Chem
  • 2001
VIEW 1 EXCERPT

The Plasmodium cell-cycle: facts and questions.

  • Annals of tropical medicine and parasitology
  • 1998