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hammerhead ribozyme

Known as: ribozyme, hammerhead 
National Institutes of Health

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Broader (1)

Catalytic RNA

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
2-Selenouridine triphosphate synthesis and Se-RNA transcription
The enzymatic synthesis of 2-selenouridine via 2-selenouridine triphosphate (SeUTP) synthesis and RNA transcription is reported… 
2010
2010
Computational mutagenesis studies of hammerhead ribozyme catalysis.
Computational studies of the mutational effects at the C3, G8, and G5 positions of the hammerhead ribozyme (HHR) are reported… 
2010
2010
Development of a reverse genetics system for a human rabies virus vaccine strain employed in China.
Review
2004
Review
2004
Therapeutic potential of hammerhead ribozymes in the treatment of hyper-proliferative diseases.
The limited efficacy of current therapeutic approaches for a number of socially relevant human diseases such as cancer and… 
Highly Cited
2003
Highly Cited
2003
Diffusely bound Mg2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core.
The hammerhead ribozyme is one of the best-studied small RNA enzymes, yet is mechanistically still poorly understood. We measured… 
2003
2003
Ribozymes—a snip too far?
  • D. Lilley
  • Nature Structural Biology
  • 2003
  • Corpus ID: 36118320
A recent study demonstrates that, when searching for the smallest active ribozymes, researchers may have thrown away parts that… 
2001
2001
An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa.
PURPOSE To develop a hammerhead ribozyme-based gene therapy for a porcine model of autosomal dominant retinitis pigmentosa (ADRP… 
Highly Cited
1999
Highly Cited
1999
High-performance liquid chromatography purification of homogenous-length RNA produced by trans cleavage with a hammerhead ribozyme.
An improved method is presented for the preparation of milligram quantities of homogenous-length RNAs suitable for nuclear… 
1996
1996
Delivery of a hammerhead ribozyme specifically down-regulates the production of fibrillin-1 by cultured dermal fibroblasts.
The hammerhead ribozyme is a small catalytic RNA molecule. Potential hammerhead ribozymes that possess a catalytic domain and… 
Highly Cited
1994
Highly Cited
1994
Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme.
A major problem in cytostatic treatment of many tumours is the development of multidrug resistance (MDR4). This is most often… 
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