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hammerhead ribozyme

Known as: ribozyme, hammerhead 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a… 
Highly Cited
2015
Highly Cited
2015
Systems for conditional gene expression are powerful tools in basic research as well as in biotechnology. For future applications… 
Review
2004
Review
2004
The limited efficacy of current therapeutic approaches for a number of socially relevant human diseases such as cancer and… 
Highly Cited
2003
Highly Cited
2003
The hammerhead ribozyme is one of the best-studied small RNA enzymes, yet is mechanistically still poorly understood. We measured… 
2001
2001
PURPOSE To develop a hammerhead ribozyme-based gene therapy for a porcine model of autosomal dominant retinitis pigmentosa (ADRP… 
Highly Cited
1999
Highly Cited
1999
An improved method is presented for the preparation of milligram quantities of homogenous-length RNAs suitable for nuclear… 
Highly Cited
1995
Highly Cited
1995
Several 2'-modified ribonucleoside phosphoramidites have been prepared for structure-activity studies of the hammerhead ribozyme… 
Highly Cited
1994
Highly Cited
1994
For the understanding of the catalytic function of the RNA hammerhead ribozyme, a three-dimensional model is essential but… 
Highly Cited
1994
Highly Cited
1994
A major problem in cytostatic treatment of many tumours is the development of multidrug resistance (MDR4). This is most often… 
Highly Cited
1993
Highly Cited
1993
The three guanosines of the central core of a hammerhead ribozyme were replaced by 2-aminopurine ribonucleoside, xanthosine…