• Publications
  • Influence
DNA Repair
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
The identification of human SLX4, a scaffold for DNA repair nucleases XPF-ERCC1, MUS81-EME1, and SLX1 is described and data show thatSLX4 is a regulator of structure-specific nucleases and that SLX 4 and SLx1 are important regulators of genome stability in human cells. Expand
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
A highly conserved protein is described, KIAA1018/MTMR15/FAN1, that interacts with, and is recruited to sites of DNA damage by, the monoubiquitinated form of FANCD2, which at least partly explains how ubiquitination of FANSCD2 promotes DNA repair. Expand
Folding of the adenine riboswitch.
The pbuE adenine riboswitch undergoes metal ion-dependent folding that involves a loop-loop interaction that strongly correlates with the ability of the loops to interact, and single-molecule FRET studies reveal that folding proceeds via a discrete intermediate. Expand
Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases
It is shown that SLX1, like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of HJ cleavage, at least in mouse cells. Expand
The structure of the holliday junction, and its resolution
The structure of a series of four-way junctions, constructed by hybridization of four 80 nucleotide synthetic oligonucleotides, is studied, showing the pattern of fragments observed argues strongly for a structure with two-fold symmetry, based on an X shape. Expand
Roles of Topoisomerases in Maintaining Steady-state DNA Supercoiling in Escherichia coli *
It is demonstrated that DNA topoisomerase IV, acting in concert with topoisomersase I and gyrase, makes an important contribution to the steady-state level of supercoiling in Escherichia coli. Expand
The high-resolution crystal structure of a parallel-stranded guanine tetraplex.
The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Expand
The junction-resolving enzymes
Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions, which poses an intriguing challenge in molecular recognition on a relatively large scale. Expand