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Receptor-mediated gene delivery and expression in vivo.
A new soluble DNA carrier system can permit targeted delivery of foreign genes specifically to liver with resultant foreign gene expression in vivo through asialoglycoprotein receptors. Expand
Characterization of an HSP70 Cognate Gene Family in Arabidopsis.
- C. Wu, T. Caspar, J. Browse, S. Lindquist, C. Somerville
- Biology, Medicine
- Plant physiology
- 1 November 1988
It appears that the three Arabidopsis genes which exhibit homology to a Drosophila HSP70 gene are members of a small family which are most closely related to the H SP70-cognate genes found in other species. Expand
Long‐term follow‐up of interferon alfa treatment in chinese patients with chronic hepatitis B infection: The effect on hepatitis B e antigen seroconversion and the development of cirrhosis‐related…
In Chinese HBsAg carriers, IFN‐α was of no long‐term benefit in inducing HBeAg seroconversion or in the prevention of hepatoma and other cirrhosis‐related complications. Expand
Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro.
We have developed a system for targeting foreign DNA to hepatocytes in vitro using a soluble DNA carrier that takes advantage of receptor-mediated endocytosis to achieve internalization. The idea is… Expand
Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers.
- C. P. Liu, K. Jiang, C. Wu, W. H. Lee, W. Lin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 19 December 2000
The generation of tetramers of I-A(g7) covalently linked to two glutamic acid decarboxylase (GAD) peptides and the detection of GAD peptide-activated T cells from nonobese diabetic (NOD) mice are reported. Expand
Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.
There is evidence that foreign DNA can be specifically delivered to cells by a soluble carrier system that takes advantage of receptor-mediated endocytosis, and that competition by a 10-fold excess of ASOR prevented gene transformation by the ASOR X poly-L-lysine X DNA complex. Expand
Delivery systems for gene therapy
The data indicate that a targetable gene delivery system can permit in vivo expression of an exogenous gene after simple intravenous injection and the foreign gene expression can be enhanced and made to persist by induction of hepatocyte replication. Expand
In vitro assembly of coiled bodies in Xenopus egg extract.
In transcriptionally active nuclei coiled bodies could serve as sites for initial preassembly and distribution of snRNP complexes for the three major RNA processing pathways: pre-mRNA splicing, pre-rRNA processing, and histone pre- mRNA 3' end formation. Expand
Cytotoxic effects of cantharidin on the growth of normal and carcinoma cells.
It is demonstrated that cantharidin could inhibit progression of all phases of the Hep 3B cell cycle and could not directly inhibit the activity of nucleic acid biosynthesis by the cellular incorporation of 3H-thymidine,3H-uridine or 3H/M phase. Expand
Somatosensory evoked potentials in subclinical portosystemic encephalopathy: A comparison with psychometric tests
SEPs were not affected by education and age and were more sensitive than psychometric tests in the assessment of subclinical PSE in better‐educated cirrhotic patients. Expand