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grandisin

National Institutes of Health

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FuransLignans

Papers overview

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2017
2017
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
2017
2017
In Vitro Inhibition of Human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by Grandisin
Abstract Grandisin, a lignan isolated from many species of plants, such as Virola surinamensis, is a potential drug candidate due… 
2017
2017
Grandisin induces apoptosis in leukemic K562 cells
In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against… 
2016
2016
Grandisin, 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6-O-glucoside, from Cassia grandis leaves - antioxidant and cytotoxic activities.
Chemical investigation of Cassia grandis leaves resulted in the isolation of the new 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6… 
2012
2012
In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity
Abstract Tetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In… 
2011
2011
Chemoprotective effect of the tetrahydrofuran lignan grandisin in the in‐vivo rodent micronucleus assay
Objectives  The chemoprotective effect of the tetrahydrofuran lignan grandisin against DNA damage induced by cyclophosphamide… 
2011
2011
In vitro basal cytotoxicity assay applied to estimate acute oral systemic toxicity of grandisin and its major metabolite.
2009
2009
Disruption of Chrysomya megacephala Growth Caused by Lignan Grandisin
ABSTRACT The toxicity of tetrahydrofuran lignan grandisin was evaluated against larvae of Chry somya megacephala F. (Diptera… 
2008
2008
Metabolism of (-)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species.
2005
2005
Estudo fitoquímico das partes aéreas de Aristolochia birostris Ducht. (Aristolochiaceae)
The family Aristolochiaceae presents among its chemical constituents terpenoids, alkaloids and lignoids. Aristolochia birostris… 
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