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Multicompartimental Nanoparticles for Co-Encapsulation and Multimodal Drug Delivery to Tumor Cells and Neovasculature
ABSTRACTPurposeThe purpose of this work was the development of a multicompartimental nanocarrier for the simultaneous encapsulation of paclitaxel (PTX) and genistein (GEN), associating antiangiogenicExpand
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Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma.
OBJECTIVE To evaluate and characterize macrophage populations (M1/M2) in the tumor microenvironment of oral cavity squamous cell carcinoma (OCSCC). The relationship between macrophages andExpand
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Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity
Campomanesia adamantium (Myrtaceae) is an antioxidant compounds-rich Brazilian fruit popularly known as gabiroba. In view of this, it was evaluated the hepatoprotective effects of pulp (GPE) orExpand
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Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release.
Topotecan is an important cytotoxic drug that has gained broad acceptance in clinical use for the treatment of refractory ovarian and small-cell lung cancer. The lactone active form of topotecan canExpand
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Ecotoxicological assessment of glyphosate-based herbicides: Effects on different organisms.
Glyphosate-based herbicides are the most commonly used worldwide because they are effective and relatively nontoxic to nontarget species. Unlimited and uncontrolled use of such pesticides can haveExpand
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Ascorbic acid encapsulated into negatively charged liposomes exhibits increased skin permeation, retention and enhances collagen synthesis by fibroblasts
Ascorbic acid (AA) is widely used in cosmetic formulations due to its antioxidant property and ability to increase collagen synthesis. Here, we encapsulated AA in vesicles with different lipidExpand
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Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice.
Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg)Expand
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Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax.
AIM OF THE STUDY Synadenium umbellatum Pax (SU), a plant used in the Midwestern region of Brazil, was tested for its antitumor and antiangiogenic activities in vitro, using K-562 and Ehrlich ascitesExpand
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Pharmacological evaluation and molecular docking of new di‐tert‐butylphenol compound, LQFM‐091, a new dual 5‐LOX/COX inhibitor
Abstract Dual 5‐LOX/COX inhibitors are potential new dual drugs to treat inflammatory conditions. This research aimed to design, synthesis and to evaluate the anti‐inflammatory and antinociceptiveExpand
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Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax.
ETHNOPHARMACOLOGICAL RELEVANCE Synadenium umbellatum Pax. is widely found in South America and empirically used in Brazil for the treatment of several diseases, mainly cancer. The aim of the studyExpand
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