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glutathione biosynthetic process

Known as: glutathione formation, glutathione biosynthesis, glutathione anabolism 
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for… 
National Institutes of Health

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glutathione synthase activity
negative regulation of glutathione biosynthetic processpositive regulation of glutathione biosynthetic process

Papers overview

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Highly Cited
2006
Highly Cited
2006
Cystine/Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation
The cystine/glutamate exchanger (xCT) provides intracellular cyst(e)ine for production of glutathione, a major cellular… 
Highly Cited
2005
Highly Cited
2005
DJ-1 Up-regulates Glutathione Synthesis during Oxidative Stress and Inhibits A53T α-Synuclein Toxicity*
DJ-1 is the third gene that has been linked to Parkinson disease. Mutations in the DJ-1 gene cause early onset PD with autosomal… 
Review
2003
Review
2003
Taurine: new implications for an old amino acid.
Highly Cited
2000
Highly Cited
2000
Astrocytes Provide Cysteine to Neurons by Releasing Glutathione
Abstract: Cysteine is the rate‐limiting precursor of glutathione synthesis. Evidence suggests that astrocytes can provide… 
Highly Cited
1997
Highly Cited
1997
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
Lipoic acid (thiotic acid) is being used as a dietary supplement, and as a therapeutic agent, and is reported to have beneficial… 
Highly Cited
1994
Highly Cited
1994
Glutathione‐related enzymes in brain in Parkinson's disease
The activities of enzymes related to glutathione synthesis, degradation, and function were analyzed in various brain regions… 
Highly Cited
1984
Highly Cited
1984
Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.
We have examined the role of the glutathione redox cycle as an antioxidant defense mechanism in cultured bovine and human… 
Highly Cited
1983
Highly Cited
1983
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
N-Acetylcysteine is the drug of choice for the treatment of an acetaminophen overdose. It is thought to provide cysteine for… 
Highly Cited
1982
Highly Cited
1982
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.
Depletion of glutathione by inhibition of its synthesis by buthionine sulfoximine, an irreversible inhibitor of gamma… 
Highly Cited
1981
Highly Cited
1981
Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.
Glutathione (in the form of GSH) is transported out of cultured human lymphoid cells at rates proportional to the intracellular… 
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