glutathione biosynthetic process

Known as: glutathione formation, glutathione biosynthesis, glutathione anabolism 
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for… (More)
National Institutes of Health

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glutathione synthase activity
negative regulation of glutathione biosynthetic process

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Review
2009
Review
2009
Regulation of glutathione synthesis.
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include detoxification, antioxidant defense… (More)
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Highly Cited
2004
Highly Cited
2004
Hydrogen sulfide protects neurons from oxidative stress
Hydrogen sulfide (H2S), which is a well-known toxic gas, is found in relatively high concentrations in the brain. Although a… (More)
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Highly Cited
2003
Highly Cited
2003
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino acid starvation, or oxidants by… (More)
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Highly Cited
2003
Highly Cited
2003
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress.
Astrocytes have a higher antioxidant potential in comparison to neurons. Pathways associated with this selective advantage… (More)
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Review
2002
Review
2002
Interactions between biosynthesis, compartmentation and transport in the control of glutathione homeostasis and signalling.
Glutathione has numerous roles in cellular defence and in sulphur metabolism. These functions depend or impact on the… (More)
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Highly Cited
2002
Highly Cited
2002
Reversible inactivation of the tumor suppressor PTEN by H2O2.
The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the 3'-phosphate of phosphoinositides… (More)
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Review
1999
Review
1999
Regulation of hepatic glutathione synthesis: current concepts and controversies.
  • Siyuan Lu
  • FASEB journal : official publication of the…
  • 1999
Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from antioxidant defense to modulation of… (More)
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Highly Cited
1998
Highly Cited
1998
Glutathione metabolic genes coordinately respond to heavy metals and jasmonic acid in Arabidopsis.
Glutathione plays a pivotal role in protecting plants from environmental stresses, oxidative stress, xenobiotics, and some heavy… (More)
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Highly Cited
1992
Highly Cited
1992
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of… (More)
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Highly Cited
1979
Highly Cited
1979
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine… (More)
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