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glutathione biosynthetic process

Known as: glutathione formation, glutathione biosynthesis, glutathione anabolism 
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for… 
National Institutes of Health

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glutathione synthase activity
negative regulation of glutathione biosynthetic processpositive regulation of glutathione biosynthetic process

Papers overview

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Highly Cited
2000
Highly Cited
2000
Induction of apoptosis by arachidonic acid in human retinoblastoma Y79 cells: involvement of oxidative stress.
Arachidonic acid administration caused apoptosis in Y79 cells, as shown by typical morphological changes, phosphatidylserine… 
Highly Cited
1998
Highly Cited
1998
Role of Endogenous Glutathione in the Oxidation of Dopamine
Abstract: Intrastriatal injection of dopamine causes the selective degeneration of tyrosine hydroxylase‐containing terminals and… 
1998
1998
Development of glutathione synthesis and gamma-glutamyltranspeptidase activities in tissues from newborn infants.
Highly Cited
1998
Highly Cited
1998
Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.
Overexpression of Bcl-2 and related anti-apoptotic gene products has been shown to increase the intracellular concentration of… 
Highly Cited
1996
Highly Cited
1996
Glutathione is an important antioxidant molecule in the yeast
The tripeptide y-L-glutamyl+cystinylglycine (glutathione) is one of the major antioxidant molecules of cells and is thought to… 
Highly Cited
1989
Highly Cited
1989
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.
Treatment of newborn rats and mice with buthionine sulfoximine, an inhibitor of glutathione synthesis, leads to development of… 
Highly Cited
1983
Highly Cited
1983
Turnover and functions of glutathione studied with isolated hepatic and renal cells.
Suspensions of freshly isolated rat hepatocytes and renal tubular cells contain high levels of reduced glutathione (GSH), which… 
Highly Cited
1983
Highly Cited
1983
Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis.
Highly Cited
1982
Highly Cited
1982
Effect of selenium deficiency and vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes.
Highly Cited
1970
Highly Cited
1970
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease.
Abstract Two enzymes are required for de novo glutathione synthesis: glutamyl-cysteine synthetase and glutathione synthetase. In… 
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