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glutathione synthase activity

Known as: GSH synthetase activity, gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming), glutathione synthetase activity 
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. [EC:6.3.2.3, RHEA:13560]
National Institutes of Health

Related topics

Related topics

2 relations
GLUTATHIONE SYNTHASE

Broader (1)

glutathione biosynthetic process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Abstract Context. Paracetamol (acetaminophen) ingestion is the most frequent pharmaceutical overdose in the developed world… 
Review
2005
Review
2005
Physiological and pathological aspects of GSH metabolism
The antioxidant glutathione is found in low levels in diseases in which increasing evidence implicate oxidative stress in the… 
2003
2003
Age-related changes in the activity of antioxidant and redox enzymes in rats.
Highly Cited
1998
Highly Cited
1998
Manipulation of glutathione and amino acid biosynthesis in the chloroplast
Poplars (Populus tremula x Populus alba) were transformed to overexpress Escherichia coli gamma-glutamylcysteine synthetase… 
Highly Cited
1990
Highly Cited
1990
λ-Glutamylcysteine synthetase in higher plants: catalytic properties and subcellular localization
Abstractλ-Glutamylcysteine synthetase activity (EC 6.3.2.2) was analysed in Sephacryl S-200 eluents of extracts from cell… 
Highly Cited
1988
Highly Cited
1988
Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes.
The zonal distribution of GSH metabolism was investigated by comparing hepatocytes obtained from the periportal (zone 1) or… 
Highly Cited
1985
Highly Cited
1985
Vitamin E and red blood cell glutathione.
Highly Cited
1981
Highly Cited
1981
Induction and repair of single-strand DNA breaks after X-irradiation of human fibroblasts deficient in glutathione.
Using the unwinding technique in weak alkali, the induction and repair of DNA single-strand breaks was determined after aerobic… 
Highly Cited
1979
Highly Cited
1979
Protection of granulocytes by vitamin E in glutathione synthetase deficiency.
The administration of vitamin E (alpha-tocopherol) was found to improve polymorphonuclear leukocyte function in an infant with… 
Highly Cited
1970
Highly Cited
1970
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease.
Abstract Two enzymes are required for de novo glutathione synthesis: glutamyl-cysteine synthetase and glutathione synthetase. In… 
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