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glutathione synthase activity

Known as: GSH synthetase activity, gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming), glutathione synthetase activity 
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. [EC:6.3.2.3, RHEA:13560]
National Institutes of Health

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2 relations
GLUTATHIONE SYNTHASE

Broader (1)

glutathione biosynthetic process

Papers overview

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1996
1996
Cloning of the cDNA and genomic clones for glutathione synthetase fromArabidopsis thaliana and complementation of agsh2 mutant in fission yeast
Glutathione is essential for protecting plants from a range of environmental stresses, including heavy metals where it acts as a… 
1995
1995
Sequencing and expression of a cDNA for human glutathione synthetase.
A human brain cDNA clone encoding glutathione synthetase (EC 6.3.2.3) has been sequenced and expressed in Escherichia coli. The… 
1994
1994
Flexible loop that is novel catalytic machinery in a ligase. Atomic structure and function of the loopless glutathione synthetase.
The catalytic mechanism of glutathione synthetase is proposed to proceed via phosphorylation of the dipeptide substrate to yield… 
Highly Cited
1988
Highly Cited
1988
Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes.
The zonal distribution of GSH metabolism was investigated by comparing hepatocytes obtained from the periportal (zone 1) or… 
1988
1988
A 13C-NMR study on the influxes into the tricarboxylic acid cycle of a renal epithelial cell line, LLC-PK1/Cl4: the metabolism of [2-13C]glycine, L-[3-13C]alanine and L-[3-13C]aspartic acid in renal…
1986
1986
Activity of glutathione synthesis enzymes in the rhesus monkey lens related to age: a model for the human lens.
The low activity level of lenticular gamma-glutamylcysteine synthetase appears to be an evolutionary phenomenon restricted to… 
1985
1985
Survival curves of glutathione synthetase deficient human fibroblasts: correlation between radiosensitivity in hypoxia and glutathione synthetase activity.
The role of intracellular non-protein bound sulphydryl compounds (NPSH), and in particular that of glutathione (GSH), in the… 
1983
1983
Purification and characterization of glutathione synthetase from Escherichia coli B.
Glutathione synthetase was purified about 60-fold with 8.5% of activity yield from the cell extracts of Escherichia coli C600… 
Highly Cited
1981
Highly Cited
1981
Induction and repair of single-strand DNA breaks after X-irradiation of human fibroblasts deficient in glutathione.
Using the unwinding technique in weak alkali, the induction and repair of DNA single-strand breaks was determined after aerobic… 
Highly Cited
1970
Highly Cited
1970
Glutathione synthetase deficiency as a cause of hereditary hemolytic disease.
Abstract Two enzymes are required for de novo glutathione synthesis: glutamyl-cysteine synthetase and glutathione synthetase. In… 
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