glutamine catabolic process

Known as: glutamine breakdown, glutamine catabolism, glutamine degradation 
The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai]
National Institutes of Health

Papers overview

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2015
2015
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
WNT signaling stimulates bone formation by increasing both the number of osteoblasts and their protein-synthesis activity. It is… (More)
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2013
2013
Loss of RBF1 changes glutamine catabolism.
Inactivation of the retinoblastoma tumor suppressor (pRB) alters the expression of a myriad of genes. To understand the altered… (More)
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Highly Cited
2012
Highly Cited
2012
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
The altered metabolism of tumors has been considered a target for anticancer therapy. However, the relationship between distinct… (More)
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Highly Cited
2011
Highly Cited
2011
Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells
α-Ketoglutarate (AKG) is a key intermediate in glutamine metabolism. Emerging evidence shows beneficial effects of AKG on… (More)
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Highly Cited
2011
Highly Cited
2011
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
Glutamine metabolism is crucial for cancer cell growth via the generation of intermediate molecules in the tricarboxylic acid… (More)
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Review
2010
Review
2010
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.
The MYC oncogene, which is frequently deregulated in human cancers, encodes a master transcription factor c-Myc (herein termed… (More)
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Highly Cited
2009
Highly Cited
2009
c-Myc suppression of miR-23 a / b enhances mitochondrial glutaminase expression and glutamine metabolism
Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes the propensity of most cancer cells to… (More)
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Highly Cited
2009
Highly Cited
2009
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.
Most cancer cells predominantly produce energy by glycolysis rather than oxidative phosphorylation via the tricarboxylic acid… (More)
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Highly Cited
2008
Highly Cited
2008
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: glucose and glutamine. Most of… (More)
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1991
1991
Mechanism of altered renal glutaminase gene expression in response to chronic acidosis.
Increased rat renal ammoniagenesis is sustained during chronic metabolic acidosis by the cell-specific induction of the… (More)
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