Nitric oxide synthases: structure, function and inhibition.
- W. Alderton, C. Cooper, Richard Graham Knowles
- BiologyBiochemical Journal
- 2001
This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our…
Nitric oxide synthases in mammals.
- Richard Graham Knowles, S. Moncada
- BiologyBiochemical Journal
- 1 March 1994
This review will describe the known biochemical mechanisms involved in the synthesis of NO from L-arginine by the NO synthases and will also describe the nature of these enzymes, their inhibition and their molecular characteristics.
1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo*
- E. Garvey, J. Oplinger, Richard Graham Knowles
- Biology, ChemistryJournal of Biological Chemistry
- 21 February 1997
The potency and selectivity of 1400W inhibition of iNOS both in vitro and in vivo were far greater than of any previously described iN OS inhibitor.
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
- Richard Graham Knowles, M. Palacios, R. Palmer, S. Moncada
- BiologyProceedings of the National Academy of Sciences…
- 1 July 1989
Results indicate that NO is formed from L-arginine in the brain through an enzymic reaction similar to that in vascular endothelial cells, neutrophils, and macrophages, adding support to the hypothesis that the formation of NO fromL-argInine is a widespread transduction mechanism for the stimulation of the soluble guanylate cyclase.
Nitric oxide synthases: structure, function and inhibition
- W. Alderton, C. Cooper, Richard Graham Knowles
- Biology
- 1 August 2001
This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our…
Induction of calcium-dependent nitric oxide synthases by sex hormones.
- C. Weiner, I. Lizasoaín, S. Baylis, Richard Graham Knowles, I. Charles, S. Moncada
- Biology, MedicineProceedings of the National Academy of Sciences…
- 24 May 1994
Both eNOS and nNOS are subject to regulation by estrogen, an action that could explain some of the changes that occur during pregnancy and some gender differences in physiology and pathophysiology.
Metabolic control.
- M. Salter, Richard Graham Knowles, C. I. Pogson
- BiologyEssays in Biochemistry
- 1994
It is assumed that the student has acquired the knowledge taught in previous courses of the degree of Biochemistry, at first and second year's level and in the first semester of the third year.
In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting β2-Adrenoceptor Agonist with 24-Hour Duration of Action
- R. Slack, V. Barrett, Richard Graham Knowles
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 January 2013
From these investigations, the data for vilanterol are consistent, showing that it is a novel, potent, and selective β2-AR receptor agonist with a long duration of action.
Nitric oxide synthase activity in human breast cancer.
- L. Thomsen, D. Miles, L. Happerfield, L. Bobrow, Richard Graham Knowles, S. Moncada
- Biology, MedicineBritish Journal of Cancer
- 1 July 1995
Calcium-dependent and -independent NO synthase activity was high in invasive tumours compared with benign or normal tissue, and for invasive ductal carcinomas, NO biosynthesis was significantly greater for grade III compared with grade II tumours.
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