glutamate-ammonia ligase activity

Known as: L-glutamine synthetase activity, glutamylhydroxamic synthetase activity, glutamine synthetase activity 
Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate. [EC:6.3.1.2, RHEA:16172]
National Institutes of Health

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Glutamate-Ammonia Ligase

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Highly Cited
2000
Highly Cited
2000
Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants.
The responses to oxidative stress induced by chronic exercise (8-wk treadmill running) or acute exercise (treadmill running to… (More)
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Highly Cited
2000
Highly Cited
2000
Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50.
Staphylococcus aureus Mu50, which has reduced susceptibility to vancomycin, has a remarkably thickened cell wall with an… (More)
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Highly Cited
1997
Highly Cited
1997
Nitrate Acts as a Signal to Induce Organic Acid Metabolism and Repress Starch Metabolism in Tobacco.
Nia30(145) transformants with very low nitrate reductase activity provide an in vivo screen to identify processes that are… (More)
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Highly Cited
1997
Highly Cited
1997
Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone.
According to the free radical theory of aging, reactive oxygen species cause oxidative damage, proposed to be an underlying… (More)
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Highly Cited
1996
Highly Cited
1996
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat.
Hypertension is strongly predicted by a low birthweight:placental weight ratio. Two independent models have been described to… (More)
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Highly Cited
1991
Highly Cited
1991
Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats.
The mechanism of brain swelling during hyperammonemia is not understood, but glutamine accumulation is consistently observed. We… (More)
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Highly Cited
1991
Highly Cited
1991
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
The relationship between Alzheimer disease (AD) and aging is not currently known. In this study, postmortem frontal- and… (More)
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Review
1990
Review
1990
Role of oxygen free radicals in carcinogenesis and brain ischemia.
Even though oxygen is necessary for aerobic life, it can also participate in potentially toxic reactions involving oxygen free… (More)
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Highly Cited
1990
Highly Cited
1990
Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.
Free radical-mediated oxidative damage has been implicated in tissue injury resulting from ischemia/reperfusion events. Global… (More)
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Highly Cited
1975
Highly Cited
1975
Regulation of nitrogen metabolism in Escherichia coli and Klebsiella aerogenes: studies with the continuous-culture technique.
Ammonia-nitrogen-limited continuous cultures of Escherichia coli and Klebsiella aerogenes contain induced levels of glutamine… (More)
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