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gemcitabine/tipifarnib

Known as: Gemcitabine/R115777, dFdC/R115777 
National Institutes of Health

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Gemcitabine hydrochloridetipifarnib

Papers overview

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2009
2009
Patient-reported outcomes as a component of the primary endpoint in a double-blind, placebo-controlled trial in advanced pancreatic cancer.
Highly Cited
2007
Highly Cited
2007
R115777 (Zarnestra®)/Zoledronic acid (Zometa®) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl‐2 and bad phosphorylation
Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of… 
2007
2007
The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in…
Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… 
2007
2007
The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro‐apoptotic activity of interferon‐α through the inhibition of multiple survival pathways
Interferon α (IFNα) induces an EGF‐Ras→Raf‐1→Erk dependent survival pathway counteracting apoptosis induced by the cytokine. In… 
2007
2007
The farnesyltransferase inhibitor R 115777 ( tipifarnib ) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and…
Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… 
2005
2005
Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS‐to‐MAP kinase signalling in multiple myeloma cells
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… 
Highly Cited
2004
Highly Cited
2004
R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways.
Ras activation is frequently observed in multiple myeloma either by mutation or through interleukin-6 receptor signaling… 
2003
2003
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
PURPOSE Inhibitors of farnesyltransferase (e.g., R115777) are being developed for therapy and prevention of various cancers. The… 
Review
2001
Review
2001
Current status of clinical trials of farnesyltransferase inhibitors
Farnesyltransferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the… 
2001
2001
A phase I, clinical and pharmacokinetic (PK) trial of the farnesyl transferase inhibitor (FTI) R115777 + docetaxel : a promising combination in patients (pts) with solid tumors
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