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ganglioside catabolic process

Known as: ganglioside breakdown, ganglioside catabolism, ganglioside degradation 
The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar… Expand
National Institutes of Health

Papers overview

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2015
2015
Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models
Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal… Expand
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2015
2015
Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals.
Transient Receptor Potential (TRP) cation channels, such as TRP Vanilloid 1 and TRP Ankyrin repeat domain 1 (TRPV1 and TRPA1) are… Expand
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Review
2013
Review
2013
Gangliosides and Gangliosidoses: Principles of Molecular and Metabolic Pathogenesis
Gangliosides are the main glycolipids of neuronal plasma membranes. Their surface patterns are generated by coordinated processes… Expand
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2008
2008
Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.
Mammalian sialidase Neu4, ubiquitously expressed in human tissues, is located in the lysosomal and mitochondrial lumen and has… Expand
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Highly Cited
2007
Highly Cited
2007
A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells
Human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is markedly upregulated in human… Expand
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2006
2006
Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.
We have found previously that human plasma-membrane-associated sialidase (NEU3), a key glycosidase for ganglioside degradation… Expand
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2005
2005
Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients
The metabolic processing of GM1 ganglioside, exogenously administered to cultured skin fibroblasts, was investigated on cells… Expand
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Review
2004
Review
2004
Secondary accumulation of gangliosides in lysosomal storage disorders.
Glycosphingolipids (GSLs) known as gangliosides have been documented to accumulate in a wide range of lysosomal storage disorders… Expand
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Highly Cited
1995
Highly Cited
1995
Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism
Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders. These two sphingolipidoses are characterized… Expand
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1985
1985
The influence of ganglioside insertion into brain membranes on the rate of ganglioside degradation by membrane-bound sialidase.
Microsomal membranes isolated from calf brain contain a sialidase which cleaves ganglioside substrates naturally occurring within… Expand
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