Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.
N, N-dimethyltryptamine: an endogenous hallucinogen.
The in vitro identification of dimethyltryptamine (DMT) in mammalian brain and its characterization as a possible endogenous neuroregulatory agent.
Dopaminergic Properties and Experimental Anti-Parkinsonian Effects of IPX750 in Rodent Models of Parkinson Disease
Results suggest that stereo-specific glycoconjugation may be an effective method to improve penetrability of drugs through the blood brain barrier and IPX-750 possesses dopaminergic properties and exerts anti-parkinsonian effects in three different PD rodent models, suggesting therapeutic potential for this new class of drugs in treating dopamine deficiency diseases.
Fluorescence Polarization Analysis, Lipid Composition, and Na+, K+‐ATPase Kinetics of Synaptosomal Membranes in Feline GM1 and GM2 Gangliosidosis
- P. A. Wood, M. McBride, H. J. Baker, S. T. Christian
- Biology, ChemistryJournal of Neurochemistry
- 1 March 1985
Observations provide evidence for a pathogenetic mechanism of neuronal dysfunction in the gangliosidoses while demonstrating protection of certain vital functional components, such as Na+, K+‐ATPase.
Synthesis and properties of a fluorescent derivative of phosphatidylcholine.
Comparison of the brain levels of N,N-dimethyltryptamine and alpha, alpha, beta, beta-tetradeutero-N-N-dimethyltryptamine following intraperitoneal injection. The in vivo kinetic isotope effect.
Interaction of psychoactive drugs with the Mg+2 requiring ATPase associated with isolated synaptic vesicles.
- L. Corbett, S. T. Christian, J. Monti, L. D. Mcclain
- Psychology, BiologyResearch communications in chemical pathology and…
- 1 August 1975
Antipsychotic agents and cocaine showed inhibition, of a non-competitive type, on the Mg+2 dependent ATPase associated with isolated synaptic vesicles, implications for a synaptic theory of psychosis are discussed.
In vivo metabolism of alpha,alpha,beta,beta-tetradeutero-N, N-dimethyltryptamine in rodent brain.
- S. Barker, J. Beaton, S. T. Christian, J. Monti, P. Morris
- Chemistry, BiologyBiochemical Pharmacology
The results of this study indicate that D4DMT is metabolized to the corresponding deutero-N-methyltryptamine, tryptamine, 1,2,3,4-tetrahydro-beta-carboline, and 2-methyl-1, 2,3-4-Tetrahytryptamine and the aforementioned metabolites in rat brain.
9-Diazomethylanthracene as a new fluorescence and ultraviolet label for the spectrometric detection of picomole quantities of fatty acids by high-pressure liquid chromatography.