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Single-Molecule Detection in Capillary Electrophoresis: Molecular Shot Noise as a Fundamental Limit to Chemical Analysis
Capillary electrophoresis is coupled with a single molecule detector based on laser-induced fluorescence. Individual molecules migrating from the capillary are detected and counted with 50%…
Capillary electrophoresis for the analysis of biopolymers.
The biosynthesis of Lewis X in Helicobacter pylori.
The biosynthesis of the Lewis X determinant in three strains of Helicobacter pylori has been investigated and the biosynthetic pathway is identical to that found in humans.
Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development
- Liangliang Sun, Michelle M. Bertke, M. Champion, G. Zhu, P. Huber, N. Dovichi
- BiologyScientific reports
- 14 March 2014
It is observed decline in the expression of ten DNA replication factors after the midblastula transition (MBT), including a marked decline of the licensing factor XCdc6, which leads to apoptosis; temporal changes in this protein are critical for proper development.
Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages.
Findings show that obesity potently affects ovarian cancer metastatic success, which likely contributes to the negative correlation between obesity and ovarian cancer survival.
Three DNA sequencing methods using capillary gel electrophoresis and laser-induced fluorescence.
Capillary gel electrophoresis is demonstrated for the four-spectral-channel sequencing technique of Smith, the two-spectral-channel sequencing technique of Prober, and the one-spectral-channel…
Third-generation electrokinetically pumped sheath-flow nanospray interface with improved stability and sensitivity for automated capillary zone electrophoresis-mass spectrometry analysis of complex…
- Liangliang Sun, G. Zhu, Zhenbin Zhang, Si Mou, N. Dovichi
- EngineeringJournal of proteome research
- 27 March 2015
A third-generation interface to couple capillary zone electrophoresis with mass spectrometry is reported that is much more robust and produces much longer lifetime than the previous designs with no loss in sensitivity.
DNA sequencing by capillary electrophoresis
- N. Dovichi
This work considered the design of large‐scale capillary instruments, wherein hundreds of DNA samples can be sequenced in parallel, and the tradeoff between read‐length and sequencing speed appears to be a fundamental result of the physics of DNA separations in a polymer.
Bioanalytical applications of capillary electrophoresis.