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ganaxolone

Known as: 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

CCD 1042

Broader (1)

Pregnanolone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Sex, Steroids, and Fear
2012
2012
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
2009
2009
Current trends in the treatment of infantile spasms
Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic epileptic… 
2008
2008
Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.
2005
2005
Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats.
Accumulating evidence suggest a reciprocal interaction between neurosteroids, especially 5alpha-pregnan-3alpha-ol,20-one (3alpha… 
2002
2002
Changes in GABAA Receptor Gene Expression Induced by Withdrawal of, but Not by Long-Term Exposure to, Ganaxolone in Cultured Rat Cerebellar Granule Cells
The effects of ganaxolone, a synthetic analog of the endogenous neuroactive steroid allopregnanolone, on the function and… 
2000
2000
Effect of ganaxolone in a rodent model of cerebral hematoma.
BACKGROUND AND PURPOSE Therapy with gamma-aminobutyric acid (GABA) agonists appears to improve outcome after experimental… 
Review
2000
Review
2000
Clinical pharmacology of new antiepileptic drugs.
Advances in neurobiology, molecular biology, and pharmaceutical science have led to the development of a number of new… 
Review
2000
Review
2000
An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development
This article evaluates rufinamide, a new anti-epileptic drug (AED) in Phase III development. This review is done against the… 
Highly Cited
1977
Highly Cited
1977
Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.
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