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Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

TLDR
These guidelines offer a framework for goal-directed treatment of the patient with intracerebral hemorrhage and are intended that this guideline be fully updated in 3 years' time.
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GABAA receptor channels.

This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA…
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Delayed neurological deterioration after subarachnoid haemorrhage

TLDR
Treatment for DCI is thought to be caused by the combined effects of angiographic vasospasm, arteriolar constriction and thrombosis, cortical spreading ischaemia, and processes triggered by EBI.
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Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

TLDR
This mini-symposium review highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents and identifies them as a major player in both physiological and pathophysiological processes.
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Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.

TLDR
An initial characterization of the electrophysiological and pharmacological properties of possible in vivo cerebellar GABAR isoforms is provided and it is demonstrated that subunit compositions of different GABar isoforms play a crucial role in determining their properties.
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Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

TLDR
These guidelines provide a framework for goal-directed treatment of the patient with intracerebral hemorrhage and follow the American Heart Association/American Stroke Association methods of classifying the level of certainty of the treatment effect and the class of evidence.
View on Wolters Kluwer (opens in a new tab)

GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

TLDR
These experiments demonstrated that the α1β3 heterodimer formed a GABAR channel with rapid deactivation and rapid and nearly complete desensitization, and represent a reconciliation of macroscopic and steady‐state single‐channel data for GAB ARs and provide a framework for systematically assessing the functional significance of different GABar isoforms.
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Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.

TLDR
The results suggest that the GABA(A) receptor delta subunit confers increased sensitivity to neurosteroid modulation and that the intrinsic gating and desensitization kinetics of alpha1beta3delta GABA( A) receptors are altered by THDOC.
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Neurosteroids Shift Partial Agonist Activation of GABAA Receptor Channels from Low- to High-Efficacy Gating Patterns

TLDR
It is suggested that neurosteroids preferentially enhance low-efficacy GABAA receptor activity independent of subunit composition, and allosteric conversion of partial to full agonism may be a general mechanism for reversibly scaling the efficacy of GAB AA receptors to endogenous partial agonists.
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It's Time to Revise the Definition of Status Epilepticus

TLDR
A revised system for defining status epilepticus is proposed that aims to clarify the situation in which a seizure persists for a sufficient length of time or is repeated frequently enough to produce a fixed and enduring epileptic condition.
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