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- Publications
- Influence
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
- L. Morgenstern, J. Hemphill, +10 authors R. Tamargo
- Medicine
- Stroke
- 1 September 2010
Purpose— The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage. Methods— A formal literature… Expand
GABAA receptor channels.
- R. Macdonald, R. Olsen
- Chemistry, Medicine
- Annual review of neuroscience
- 1994
This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA… Expand
Delayed neurological deterioration after subarachnoid haemorrhage
- R. Macdonald
- Medicine
- Nature Reviews Neurology
- 2014
Subarachnoid haemorrhage (SAH) causes early brain injury (EBI) that is mediated by effects of transient cerebral ischaemia during bleeding plus effects of the subarachnoid blood. Secondary effects of… Expand
Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies: Proposal of a Multidisciplinary Research Group
- M. Vergouwen, M. Vermeulen, +12 authors Y. Roos
- Medicine
- Stroke
- 1 October 2010
Background and Purpose— In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal… Expand
Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function
- D. Belelli, N. Harrison, J. Maguire, R. Macdonald, M. Walker, D. Cope
- Biology, Medicine
- The Journal of Neuroscience
- 14 October 2009
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been… Expand
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.
- N. Saxena, R. Macdonald
- Biology, Medicine
- Molecular pharmacology
- 1 March 1996
Analysis of the composition of cerebellar gamma-aminobutyric acidA (GABAA) receptors (GABARs) with in situ hybridization of GABAR subunit subtype mRNAs [J. Neurosci 12:1063-1076 (1992)] and Western… Expand
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
- J. Hemphill, S. Greenberg, +10 authors D. Woo
- Medicine
- Stroke
- 1 July 2015
Purpose— The aim of this guideline is to present current and comprehensive recommendations for the diagnosis and treatment of spontaneous intracerebral hemorrhage. Methods— A formal literature search… Expand
Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
- Timour Al-Khindi, R. Macdonald, T. Schweizer
- Medicine
- Stroke
- 1 August 2010
Background and Purpose— Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency characterized by the accumulation of blood in the subarachnoid space surrounding the brain. The acute… Expand
It's Time to Revise the Definition of Status Epilepticus
- D. Lowenstein, T. Bleck, R. Macdonald
- Medicine
- Epilepsia
- 1 January 1999
Generalized, tonic-clonic status epilepticus is well recognized as a common neurologic emergency requir- ing prompt treatment. The diagnosis is usually not diffi- cult, other than for patients with… Expand
Rapid Seizure-Induced Reduction of Benzodiazepine and Zn2+ Sensitivity of Hippocampal Dentate Granule Cell GABAA Receptors
- J. Kapur, R. Macdonald
- Chemistry, Medicine
- The Journal of Neuroscience
- 1 October 1997
Fast synaptic inhibition in the forebrain is mediated primarily by GABA acting on GABAA receptors (GABARs). GABARs are regulated by numerous positive (barbiturates, benzodiazepines, and… Expand
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