• Publications
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Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
TLDR
These guidelines offer a framework for goal-directed treatment of the patient with intracerebral hemorrhage and are intended that this guideline be fully updated in 3 years' time. Expand
GABAA receptor channels.
This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABAExpand
Delayed neurological deterioration after subarachnoid haemorrhage
TLDR
Treatment for DCI is thought to be caused by the combined effects of angiographic vasospasm, arteriolar constriction and thrombosis, cortical spreading ischaemia, and processes triggered by EBI. Expand
Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies: Proposal of a Multidisciplinary Research Group
TLDR
An international ad hoc panel of experts involved in subarachnoid hemorrhage research developed and proposed a definition of DCI to be used as an outcome measure in clinical trials and observational studies, which reflect the most relevant morphological and clinical features ofDCI. Expand
Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function
TLDR
This mini-symposium review highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents and identifies them as a major player in both physiological and pathophysiological processes. Expand
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.
TLDR
An initial characterization of the electrophysiological and pharmacological properties of possible in vivo cerebellar GABAR isoforms is provided and it is demonstrated that subunit compositions of different GABar isoforms play a crucial role in determining their properties. Expand
Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
TLDR
Much remains to be learned about the brain changes underlying cognitive and functional deficits, including the role of diffuse brain damage and secondary complications like vasospasm and elevated intracranial pressure. Expand
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
TLDR
These guidelines provide a framework for goal-directed treatment of the patient with intracerebral hemorrhage and follow the American Heart Association/American Stroke Association methods of classifying the level of certainty of the treatment effect and the class of evidence. Expand
It's Time to Revise the Definition of Status Epilepticus
TLDR
A revised system for defining status epilepticus is proposed that aims to clarify the situation in which a seizure persists for a sufficient length of time or is repeated frequently enough to produce a fixed and enduring epileptic condition. Expand
Rapid Seizure-Induced Reduction of Benzodiazepine and Zn2+ Sensitivity of Hippocampal Dentate Granule Cell GABAA Receptors
TLDR
The development of rapid functional plasticity of GABARs occurring over 45 min of continuous seizures (status epilepticus) in rats is reported and it is concluded that the prolonged seizures of status epileptus rapidly altered the functional properties of hippocampal dentate granule cell GABARS. Expand
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