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The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion (predominantly Cl−)-permeant GABAAExpand
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Cation-Chloride Cotransporters and Neuronal Function
Recent years have witnessed a steep increase in studies on the diverse roles of neuronal cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription, posttranslationalExpand
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Cation–chloride co-transporters in neuronal communication, development and trauma
Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and carriers that establish transmembrane ion gradients, and on the operation of ion channels that generate currentExpand
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Ionic basis of GABAA receptor channel function in the nervous system
  • K. Kaila
  • Biology, Medicine
  • Progress in Neurobiology
  • 1 March 1994
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Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep.
Human cortical activity has been intensively examined at frequencies ranging from 0.5 Hz to several hundred Hz. Recent studies have, however, reported also infraslow fluctuations in neuronalExpand
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Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampalExpand
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Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades,Expand
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Phase Synchrony among Neuronal Oscillations in the Human Cortex
Synchronization of neuronal activity, often associated with network oscillations, is thought to provide a means for integrating anatomically distributed processing in the brain. Neuronal processing,Expand
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Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy
Changes in chloride (Cl−) homeostasis may be involved in the generation of some epileptic activities. In this study, we asked whether Cl− homeostasis, and thus GABAergic signaling, is altered inExpand
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BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion
Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl− regulation, which can lead to a suppression of fast postsynapticExpand
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